apoA-I binds to CUBN:AMN

Stable Identifier
R-HSA-264848
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Extracellular apoA-I protein binds to the CUBN (cubilin) subunit of the CUBN:AMN complex associated with the plasma membrane. In the body, this complex is found on the apical surfaces of kidney glomerular cells, where it mediates binding and endocytosis of proteins in the glomerular filtrate, and on the apical surfaces of enterocytes, where it mediates uptake of several vitamins complexed with carrier proteins (notably vitamin B12 (cobalamin):intrinsic factor) (Kozyraki et al. 1999; Fyfe et al. 2004).

Literature References
PubMed ID Title Journal Year
17652309 Apolipoprotein A-II is catabolized in the kidney as a function of its plasma concentration

Dugué-Pujol, S, Rousset, X, Château, D, Pastier, D, Klein, C, Demeurie, J, Cywiner-Golenzer, C, Chabert, M, Verroust, PJ, Chambaz, J, Châtelet, FP, Kalopissis, AD

J Lipid Res 2007
10371504 The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein

Kozyraki, R, Fyfe, JC, Kristiansen, M, Gerdes, C, Jacobsen, C, Cui, S, Christensen, EI, Aminoff, M, de la Chapelle, A, Krahe, R, Verroust, PJ, Moestrup, SK

Nat Med 1999
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