Reactome | BMP1-3 [extracellular region]

BMP1-3 [extracellular region]

Stable Identifier

R-HSA-264768

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

mTLD, mammalian tolloid homologue, Bone morphogenetic protein 1, Procollagen C-proteinase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P13497-3 BMP1

Gene Names

BMP1, PCOLC

Participates

as a component of

BMP1-3:Zn2+ [extracellular region] (Homo sapiens)

Inferred To

BMP1 [extracellular region] (Bos taurus)

BMP1 [extracellular region] (Sus scrofa)

bmp1a [extracellular region] (Danio rerio)

BMP1-3 [extracellular region] (Canis familiaris)

Bmp1 [extracellular region] (Mus musculus)

Bmp1 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_006120.1, NP_001190.1, XP_011542919.1, XP_016869227.1

Guide to Pharmacology - Targets

2333

OpenTargets

ENSG00000168487

ENSEMBL

ENSG00000168487, ENSP00000428332, ENSP00000306121, ENST00000520970, ENSP00000428665, ENSP00000305714, ENST00000306385, ENSP00000430406, ENST00000471755, ENST00000521385, ENST00000306349

ZINC - Substances

BMP1_HUMAN

ZINC target

P13497

PRO

P13497

PDB

6BTN, 3EDH, 3EDG, 6BSL, 6BTP, 6BTQ, 6BSM, 6BTO

IntEnz

3.4.24.19

HPA

ENSG00000168487-BMP1

GeneCards

BMP1

Pharos - Targets

P13497

Orphanet

BMP1

ZINC - Predictions - Purchasable

BMP1_HUMAN

HMDB Protein

HMDBP09433

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
calcium(2+) [ChEBI:29108]	20	Ca2+ [endosome membrane] (R-ALL-5210949) Ca2+ [platelet dense granule lumen] (R-ALL-114582) Ca2+ [sarcoplasmic reticulum lumen] (R-ALL-2855229) Ca2+ [mitochondrial intermembrane space] (R-ALL-8949232) Ca2+ [lysosomal lumen] (R-ALL-1606834) Ca2+ [endocytic vesicle lumen] (R-ALL-8851519) Ca2+ [mitochondrial matrix] (R-ALL-8949220) Ca2+ [endoplasmic reticulum-Golgi intermediate compartment] (R-ALL-9706979) Ca2+ [Golgi lumen] (R-ALL-167012) Ca2+ [platelet dense tubular network lumen] (R-ALL-139827) Ca2+ [platelet dense tubular network membrane] (R-ALL-141090) Ca2+ [plasma membrane] (R-ALL-140648) Ca2+ [secretory granule lumen] (R-ALL-216801) Ca2+ [nuclear envelope] (R-ALL-2318767) Ca2+ [nucleoplasm] (R-ALL-29496) Ca2+ [mitochondrial inner membrane] (R-ALL-1524102) Ca2+ [endoplasmic reticulum membrane] (R-ALL-1500625) Ca2+ [cytosol] (R-ALL-74016) Ca2+ [extracellular region] (R-ALL-74112) Ca2+ [endoplasmic reticulum lumen] (R-ALL-111875)	0.544	5
UniProt:Q12996 CSTF3	1	CSTF3 [nucleoplasm] (R-HSA-72005)	0.527	2
UniProt:P11021 HSPA5	7	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [plasma membrane] (R-HSA-9922467) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2
UniProt:Q6VN20 RANBP10	1	RANBP10 [cytosol] (R-HSA-8851865)	0.527	2
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.527	2
UniProt:P59665 DEFA1	9	DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053) DEFA1(65-94) [extracellular region] (R-HSA-1462022) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397)	0.527	2
UniProt:O60934 NBN	3	p-S343-NBN [nucleoplasm] (R-HSA-75237) NBN [cytosol] (R-HSA-5684005) NBN [nucleoplasm] (R-HSA-75163)	0.527	2
UniProt:O60216 RAD21	14	RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775) p-S454-RAD21 [chromosome] (R-HSA-2485164) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [cytosol] (R-HSA-2500308) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21 [cytosol] (R-HSA-2484795) monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183)	0.527	2
UniProt:Q05048 CSTF1	1	CSTF1 [nucleoplasm] (R-HSA-72001)	0.527	2

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