Reactome | BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1

BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1

Stable Identifier

R-HSA-264758

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The six aminoterminal residues of pro-apolipoprotein A-1 are removed to generate the mature, lipid-binding form of the protein (APOA1). Studies of tissue culture systems suggest that BMP1 catalyzes this reaction (Chau et al. 2006, 2007). While BMP1 is annotated here as a monomer, its subunit structure is not known, and its 1:1 association with Zn2+ is inferred from its sequence similarity to known metallopeptidases. Tetrameric alpha2-macroglobulin (A2M) at concentrations found in plasma in inflammatory responses inhibits this reaction in vitro, suggesting a possible link between inflammation and perturbation of HDL function (Zhang et al. 2006, Chau et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17580958	Bone morphogenetic protein-1 (BMP-1) cleaves human proapolipoprotein A1 and regulates its activation for lipid binding Chau, P, Fielding, PE, Fielding, CJ	Biochemistry	2007
17071617	Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin Zhang, Y, Ge, G, Greenspan, DS	J Biol Chem	2006
16548525	Mechanism of prebeta-HDL formation and activation Chau, P, Fielding, PE, Nakamura, Y, Fielding, CJ	Biochemistry	2006