Serum albumin binds 2-lysophosphatidylcholine

Stable Identifier
R-HSA-264679
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
2 2-lysophosphatidylcholine + serum albumin => albumin:2-lysophosphatidylcholine complex
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Serum albumin binds 2-lysophosphatidylcholine (lysolecithin) to form a complex. Two molecules of lipid bind strongly to a molecule of albumin; an additional five molecules bind more weakly (Nakagawa and Nishida 1973). The fate of the complex in vivo is unclear. In vitro 2-lysophosphatidylcholine can be esterified with fatty acid to generate phosphatidylcholine. Such a process could replenish the phosphatidylcholine consumed by cholesterol esterification in HDL particles, but the extent to which it occurs in vivo is unclear (Nakagawa and Nishida 1973; Switzer and Eder 1965).

Literature References
PubMed ID Title Journal Year
4360812 Effect of lysolecithin and albumin on lecithin-cholesterol acyltransferase activity in human plasma

Nakagawa, M, Nishida, T

J Biochem 1973
5865378 Transport of lysolecithin by albumin in human and rat plasma

Switzer, S, Eder, HA

J Lipid Res 1965
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