Reactome | Proteasome mediated degradation of COP1

Proteasome mediated degradation of COP1

Stable Identifier

R-HSA-264458

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
        
        Proteasome mediated degradation of COP1 (Homo sapiens)

General

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Autoubiquitinated COP1 is degraded by the proteasome. The number of ubiquitin molecules shown in this reaction is arbitrarily set at 4. (Dornan et al., 2006).

Literature References

PubMed ID	Title	Journal	Year
16931761	ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage Dixit, VM, Shimizu, H, O'Rourke, K, Eby, M, Dornan, D, Dudhela, T, Mah, A, Seshagiri, S	Science	2006