Proteasome mediated degradation of COP1

Stable Identifier
R-HSA-264458
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
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Proteasome mediated degradation of COP1
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Autoubiquitinated COP1 is degraded by the proteasome. The number of ubiquitin molecules shown in this reaction is arbitrarily set at 4. (Dornan et al., 2006).

Literature References
PubMed ID Title Journal Year
16931761 ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage

Dornan, D, Shimizu, H, Mah, A, Dudhela, T, Eby, M, O'Rourke, K, Seshagiri, S, Dixit, VM

Science 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
26S proteasome [cytosol]
Activity
endopeptidase activity (0004175)
Orthologous Events
Proteasome mediated degradation of COP1 (Caenorhabditis elegans)
Proteasome mediated degradation of COP1 (Canis familiaris)
Proteasome mediated degradation of COP1 (Danio rerio)
Proteasome mediated degradation of COP1 (Dictyostelium discoideum)
Proteasome mediated degradation of COP1 (Mus musculus)
Proteasome mediated degradation of COP1 (Rattus norvegicus)
Proteasome mediated degradation of COP1 (Sus scrofa)
Proteasome mediated degradation of COP1 (Xenopus tropicalis)
Authored
Matthews, L  (2008-06-13)
Reviewed
Dixit, VM  (2009-11-17)
Created
Matthews, L  (2008-03-31)
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