Proteasome mediated degradation of COP1

Stable Identifier
R-HSA-264458
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Proteasome mediated degradation of COP1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Autoubiquitinated COP1 is degraded by the proteasome. The number of ubiquitin molecules shown in this reaction is arbitrarily set at 4. (Dornan et al., 2006).

Literature References
PubMed ID Title Journal Year
16931761 ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage

Dixit, VM, Shimizu, H, O'Rourke, K, Eby, M, Dornan, D, Dudhela, T, Mah, A, Seshagiri, S

Science 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteasome mediated degradation of COP1 (Caenorhabditis elegans)
Proteasome mediated degradation of COP1 (Canis familiaris)
Proteasome mediated degradation of COP1 (Danio rerio)
Proteasome mediated degradation of COP1 (Dictyostelium discoideum)
Proteasome mediated degradation of COP1 (Mus musculus)
Proteasome mediated degradation of COP1 (Rattus norvegicus)
Proteasome mediated degradation of COP1 (Sus scrofa)
Authored
Matthews, L  (2008-06-12)
Reviewed
Dixit, VM  (2009-11-17)
Created
Matthews, L  (2008-03-31)
Cite Us!