at-retinyl is hydrolysed from p-MII:SAG to release atRAL

Stable Identifier
R-HSA-2632521
Type
Reaction [transition]
Species
Homo sapiens
Compartment
photoreceptor disc membrane, cytosol
ReviewStatus
5/5
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at-retinyl is hydrolysed from p-MII:SAG to release atRAL
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Eventually the Schiff base linkage between the all-trans-retinyl (at-retinyl) group and opsin is hydrolyzed, releasing all-trans-retinal (atRAL). atRAL repositions to an "exit" site within opsin and is reduced to all-trans-retinol (atROL) by retinol dehydrogenases RDH8 and RDH12 using NADPH as cofactor (see section on rod retinoid cycle), whereupon it exits the rod (Baumann & Bender 1973).

Literature References
PubMed ID Title Journal Year
4772407 Kinetics of rhodopsin bleaching in the isolated human retina

Baumann, C, Bender, S

J. Physiol. (Lond.) 1973
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Orthologous Events
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Bos taurus)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Danio rerio)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Gallus gallus)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Mus musculus)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Rattus norvegicus)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Sus scrofa)
Authored
Jassal, B  (2012-11-21)
Reviewed
Makino, C  (2013-04-11)
Created
Jassal, B  (2012-11-21)
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