AJUBA facilitates AURKA autophosphorylation

Stable Identifier
R-HSA-2574840
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AURKA (Aurora A kinase) activation through autophosphorylation of threonine T288 is facilitated by AJUBA binding. AJUBA is also phosphorylated by AURKA on an unidentified serine or threonine residue (Hirota et al. 2003).

Literature References
PubMed ID Title Journal Year
13678582 Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

Hirota, T, Kunitoku, N, Sasayama, T, Marumoto, T, Zhang, D, Nitta, M, Hatakeyama, K, Saya, H

Cell 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Centrosome:AURKA:AJUBA [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created