Cytosolic iron-sulfur cluster assembly

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Homo sapiens
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Iron-sulfur clusters containing 4 atoms of iron and 4 atoms of sulfur (4Fe-4S clusters) are assembled in the cytosol on a heterotetrameric scaffold composed of NUBP2 and NUBP1 subunits (reviewed in Lill et al. 2012, Rouault et al. 2012, Sharma et al. 2010, Lill and Muhlenhoff 2006). The sources of iron and sulfur are uncertain but the process requires a sulfur-containing compound exported from mitochondria via ABCB7 (ABC7). Newly synthesized 4Fe-4S are transferred to apoproteins such as XPD and POLD1 via the CIA targeting complex, composed of NARFL, CIAO1, FAM96B, and MMS19.

Literature References
PubMed ID Title Journal Year
20522543 Cytosolic iron-sulfur cluster assembly (CIA) system: factors, mechanism, and relevance to cellular iron regulation

Pallesen, LJ, Walden, WE, Spang, RJ, Sharma, AK

J. Biol. Chem. 2010
22382365 Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

Rouault, TA

Dis Model Mech 2012
22609301 The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism

Webert, H, Pierik, AJ, Lill, R, Hoffmann, B, Stehling, O, Uzarska, MA, Wilbrecht, C, Rietzschel, N, Mühlenhoff, U, Molik, S

Biochim. Biophys. Acta 2012
16824008 Iron-sulfur protein biogenesis in eukaryotes: components and mechanisms

Lill, R, Mühlenhoff, U

Annu. Rev. Cell Dev. Biol. 2006
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