Cytosolic Fe/S protein biogenesis depends on the electron transfer chain from NAD(P)H to the Fe/S protein (CIAPIN1 in humans, DRE2 in yeast) via the flavoprotein NDOR1 (TAH18 in yeast). The precise role of electrons in the assembly process is unclear but in the absence of the electron chain the stable [4Fe-4S] cluster of NUBP1 is not assembled. CIAPIN1 binds two Fe/S clusters of the [2Fe-2S] and the [4Fe-4S] type. The [2Fe-2S] cluster is reduced by NDOR1-NADPH.
Netz, DJ, Pierik, AJ, Doré, C, Lill, R, Stümpfig, M, Mühlenhoff, U
Pain, D, Dancis, A, Lyver, ER, Bi, E, Daldal, F, Zhang, Y, Ohnishi, T, Yoon, H, Lee, DW, Amutha, B, Nakamaru-Ogiso, E
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