NADPH reduces NDOR1:CIAPIN1

Stable Identifier
R-HSA-2564824
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Cytosolic Fe/S protein biogenesis depends on the electron transfer chain from NAD(P)H to the Fe/S protein (CIAPIN1 in humans, DRE2 in yeast) via the flavoprotein NDOR1 (TAH18 in yeast). The precise role of electrons in the assembly process is unclear but in the absence of the electron chain the stable [4Fe-4S] cluster of NUBP1 is not assembled. CIAPIN1 binds two Fe/S clusters of the [2Fe-2S] and the [4Fe-4S] type. The [2Fe-2S] cluster is reduced by NDOR1-NADPH.

Literature References
PubMed ID Title Journal Year
18625724 Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis

Zhang, Y, Lyver, ER, Nakamaru-Ogiso, E, Yoon, H, Amutha, B, Lee, DW, Bi, E, Ohnishi, T, Daldal, F, Pain, D, Dancis, A

Mol. Cell. Biol. 2008
20802492 Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis

Netz, DJ, Stümpfig, M, Doré, C, Mühlenhoff, U, Pierik, AJ, Lill, R

Nat. Chem. Biol. 2010
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