Phosphorylated OPTN translocates to the nucleus

Stable Identifier
R-HSA-2562594
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated OPTN translocates to the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of OPTN (optineurin) on serine S177 by PLK1 promotes translocation of OPTN to the nucleus (Kachaner et al. 2012).

Literature References
PubMed ID Title Journal Year
22365832 Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression

Kachaner, D, Filipe, J, Laplantine, E, Bauch, A, Bennett, KL, Superti-Furga, G, Israel, A, Weil, R

Mol. Cell 2012
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Phosphorylated OPTN translocates to the nucleus (Bos taurus)
Phosphorylated OPTN translocates to the nucleus (Canis familiaris)
Phosphorylated OPTN translocates to the nucleus (Danio rerio)
Phosphorylated OPTN translocates to the nucleus (Drosophila melanogaster)
Phosphorylated OPTN translocates to the nucleus (Gallus gallus)
Phosphorylated OPTN translocates to the nucleus (Mus musculus)
Phosphorylated OPTN translocates to the nucleus (Rattus norvegicus)
Phosphorylated OPTN translocates to the nucleus (Sus scrofa)
Phosphorylated OPTN translocates to the nucleus (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-01-29)
Reviewed
Weil, R  (2013-02-07)
Created
Orlic-Milacic, M  (2012-11-06)