Phosphorylated OPTN translocates to the nucleus

Stable Identifier
R-HSA-2562594
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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Phosphorylated OPTN translocates to the nucleus
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Phosphorylation of OPTN (optineurin) on serine S177 by PLK1 promotes translocation of OPTN to the nucleus (Kachaner et al. 2012).

Literature References
PubMed ID Title Journal Year
22365832 Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression

Kachaner, D, Filipe, J, Laplantine, E, Bauch, A, Bennett, KL, Superti-Furga, G, Israel, A, Weil, R

Mol. Cell 2012
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Output
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Orthologous Events
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Phosphorylated OPTN translocates to the nucleus (Drosophila melanogaster)
Phosphorylated OPTN translocates to the nucleus (Gallus gallus)
Phosphorylated OPTN translocates to the nucleus (Mus musculus)
Phosphorylated OPTN translocates to the nucleus (Rattus norvegicus)
Phosphorylated OPTN translocates to the nucleus (Sus scrofa)
Phosphorylated OPTN translocates to the nucleus (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-01-29)
Reviewed
Weil, R  (2013-02-07)
Created
Orlic-Milacic, M  (2012-11-06)
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