TRIF was repored to efficiently induce apoptosis when overexpressed in human HEK293T cells. TRIF-induced apoptosis occurred through activation of the FADD-caspase-8 axis (Kaiser WJ and Offermann MK 2005; Kalai M et al. 2002; Estornes Y et al. 2012). C-terminus of TRIF was shown to form complexes with both RIP1 and RIP3, and disruption of these interactions by mutating the RHIM eliminated the ability of TRIF to induce apoptosis (Kaiser WJ and Offermann MK 2005).
Prevention of RIP1 ubiquitination leads to a strong association of RIP1 and caspase-8 (Feoktistova M et al. 2011, Tenev et al. 2011).
Offermann, MK, Kaiser, WJ
Conroy, H, Martin, SJ, Creagh, EM
Zachariou, A, Langlais, C, Darding, M, Tenev, T, Cain, K, Bianchi, K, MacFarlane, M, Lopez, J, Meier, P, Broemer, M, Wallberg, F
Zhang, J, Shu, HB, Han, KJ, Bin, LH, Su, X, Xu, LG
Langlais, C, Geserick, P, Kellert, B, Häcker, G, Cain, K, Feoktistova, M, Hupe, M, MacFarlane, M, Leverkus, M, Dimitrova, DP
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