PLK1 phosphorylates OPTN

Stable Identifier
R-HSA-2562526
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
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PLK1 phosphorylates OPTN
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Activated PLK1 phosphorylates OPTN (optineurin) on serine residue S177. Phosphorylation at S177 disrupts OPTN binding to Golgi-membrane localized RAB8A (Kachaner et al. 2012).

Literature References
PubMed ID Title Journal Year
22365832 Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression

Kachaner, D, Filipe, J, Laplantine, E, Bauch, A, Bennett, KL, Superti-Furga, G, Israel, A, Weil, R

Mol. Cell 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T210-PLK1 [cytosol]
Physical Entity
p-T210-PLK1 [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
PLK1 phosphorylates OPTN (Bos taurus)
PLK1 phosphorylates OPTN (Canis familiaris)
PLK1 phosphorylates OPTN (Danio rerio)
PLK1 phosphorylates OPTN (Drosophila melanogaster)
PLK1 phosphorylates OPTN (Gallus gallus)
PLK1 phosphorylates OPTN (Mus musculus)
PLK1 phosphorylates OPTN (Rattus norvegicus)
PLK1 phosphorylates OPTN (Sus scrofa)
PLK1 phosphorylates OPTN (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-01-29)
Reviewed
Weil, R  (2013-02-07)
Created
Orlic-Milacic, M  (2012-11-06)