PLK1 phosphorylates OPTN

Stable Identifier
R-HSA-2562526
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated PLK1 phosphorylates OPTN (optineurin) on serine residue S177. Phosphorylation at S177 disrupts OPTN binding to Golgi-membrane localized RAB8A (Kachaner et al. 2012).

Literature References
PubMed ID Title Journal Year
22365832 Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression

Kachaner, D, Filipe, J, Laplantine, E, Bauch, A, Bennett, KL, Superti-Furga, G, Israel, A, Weil, R

Mol. Cell 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T210-PLK1 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created