Reactome | Collagen type IV sulfilimine cross-linking by peroxidasin

Collagen type IV sulfilimine cross-linking by peroxidasin

Stable Identifier

R-HSA-2559639

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Collagen type IV sulfilimine cross-linking by peroxidasin

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A recently discovered sulfilimine (S=N) bond between a methionine sulfur and hydroxylysine nitrogen reinforces the collagen IV network (Vanacore et al. 2005, 2009). Peroxidasin, an enzyme found in basement membranes, indirectly catalyzes formation of the sulfilimine bond by producing the reactive intermediates hypobromous acid from peroxide and free Br- (Bhave 2012, MacCall et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
22842973	Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis Bhave, G, Cummings, CF, Vanacore, RM, Kumagai-Cresse, C, Ero-Tolliver, IA, Rafi, M, Kang, JS, Pedchenko, V, Fessler, LI, Fessler, JH, Hudson, BG	Nat. Chem. Biol.	2012
19729652	A sulfilimine bond identified in collagen IV Vanacore, RM, Ham, AJ, Voehler, M, Sanders, CR, Conrads, TP, Veenstra, TD, Sharpless, KB, Dawson, PE, Hudson, BG	Science	2009