TLR1/2 ligand binds to CD14

Stable Identifier
R-HSA-2559468
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TLR1/2 ligand binds to CD14
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CD14, a GPI-anchored molecule found on the cell surface of human phagocytes, has been identified as a co-receptor that interacts with LPS. CD14 has been also implicated in TLR-2 signalling [Hajishengallis G et al 2006; Zivkovic A et al 2011]. Studies have demonstrated that CD14 can bind to triacylated lipoproteins and mediate the activation of the innate immune system trough TLR2:TLR1 complex [Nakata T et al 2006; Manukyan M et al 2005; Triantafilou M et al 2006]

Literature References
PubMed ID Title Journal Year
16880211 Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

Triantafilou, M, Gamper, FG, Haston, RM, Mouratis, MA, Morath, S, Hartung, T, Triantafilou, K

J. Biol. Chem. 2006
15714590 Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1

Manukyan, M, Triantafilou, K, Triantafilou, M, Mackie, A, Nilsen, N, Espevik, T, Wiesmüller, KH, Ulmer, AJ, Heine, H

Eur. J. Immunol. 2005
Participants
Input
Output
Participant Of
hasEvent
Authored
Shamovsky, V  (2012-05-15)
Reviewed
Granucci, F  (2012-11-13)
Zanoni, I  (2012-11-13)
Created
Shamovsky, V  (2012-11-02)