CD14, a GPI-anchored molecule found on the cell surface of human phagocytes, has been identified as a co-receptor that interacts with LPS. CD14 has been also implicated in TLR-2 signalling [Hajishengallis G et al 2006; Zivkovic A et al 2011]. Studies have demonstrated that CD14 can bind to triacylated lipoproteins and mediate the activation of the innate immune system trough TLR2:TLR1 complex [Nakata T et al 2006; Manukyan M et al 2005; Triantafilou M et al 2006]
Triantafilou, M, Gamper, FG, Haston, RM, Mouratis, MA, Morath, S, Hartung, T, Triantafilou, K
Manukyan, M, Triantafilou, K, Triantafilou, M, Mackie, A, Nilsen, N, Espevik, T, Wiesmüller, KH, Ulmer, AJ, Heine, H
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