Progesterone Activation Of CatSper

Stable Identifier
R-HSA-2534388
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Progesterone Activation Of CatSper
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Steroid hormone progesterone released by cumulus cells surrounding the egg is a potent stimulator of human spermatozoa. It attracts spermatozoa towards the egg and helps them penetrate the egg's protective vestments. Progesterone induces Ca2+ influx into spermatozoa and triggers multiple Ca2+-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the egg. Progesterone dramatically potentiates CatSper calcium transport activity, identifying CatSper as the progesterone receptor of sperm.

Literature References
PubMed ID Title Journal Year
21412338 The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm

Weyand, I, Brenker, C, Goodwin, N, Seifert, R, Strünker, T, Kaupp, UB, Kashikar, ND

Nature 2011
21412339 Progesterone activates the principal Ca2+ channel of human sperm

Botchkina, IL, Lishko, PV, Kirichok, Y

Nature 2011
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Orthologous Events
Progesterone Activation Of CatSper (Bos taurus)
Progesterone Activation Of CatSper (Canis familiaris)
Progesterone Activation Of CatSper (Mus musculus)
Progesterone Activation Of CatSper (Rattus norvegicus)
Progesterone Activation Of CatSper (Sus scrofa)
Authored
Gillespie, ME  (2013-02-13)
Reviewed
Lishko, PV  (2013-05-21)
Created
Gillespie, ME  (2012-10-25)
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