Slo3 Potassium Transport

Stable Identifier
R-HSA-2534365
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Slo3 represents a new and unique type of potassium channel regulated by intracellular pH. Slo3 is sperm specific and controls membrane potential. Incapacitated murine spermatozoa hyperpolarize to approximately 60 mV during capacitation, an effect attributed to an increase in K+ permeability. KSper (potassium transport in sperm) is the dominant, if not the only, K+ selective channel in mouse epididymal spermatozoa.

Literature References
PubMed ID Title Journal Year
17460039 KSper, a pH-sensitive K+ current that controls sperm membrane potential

Navarro, B, Kirichok, Y, Clapham, DE

Proc. Natl. Acad. Sci. U.S.A. 2007
9452476 Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes

Schreiber, M, Wei, A, Yuan, A, Gaut, J, Saito, M, Salkoff, L

J. Biol. Chem. 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
potassium channel activity of Slo3 Channel [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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