PSEN1

Stable Identifier
R-HSA-2534316
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
PS1, Presenillin-1, PSEN1 dimer
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15147205 Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

Knappenberger, KS, Tian, G, Ye, X, Sobotka-Briner, C, Ghanekar, SV, Greenberg, BD, Scott, CW

Biochemistry 2004
24781550 Therapeutic modulation of Notch signalling--are we there yet?

Andersson, ER, Lendahl, U

Nat Rev Drug Discov 2014
20445084 Structural investigation of the C-terminal catalytic fragment of presenilin 1

Sobhanifar, S, Schneider, B, Löhr, F, Gottstein, D, Ikeya, T, Mlynarczyk, K, Pulawski, W, Ghoshdastider, U, Kolinski, M, Filipek, S, Güntert, P, Bernhard, F, Dötsch, V

Proc. Natl. Acad. Sci. U.S.A. 2010
9173929 Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue

Podlisny, MB, Citron, M, Amarante, P, Sherrington, R, Xia, W, Zhang, J, Diehl, T, Levesque, G, Fraser, P, Haass, C, Koo, EH, Seubert, P, St George-Hyslop, P, Teplow, DB, Selkoe, DJ

Neurobiol. Dis. 1997
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