HSPG2 (perlecan) degradation by MMP14, MMP15

Stable Identifier
R-HSA-2534240
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Synonyms
Degradation of perlecan by MMP14, MMP15
ReviewStatus
5/5
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HSPG2 (perlecan) degradation by MMP14, MMP15
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HSPG2 protein (perlecan) consists of a core protein of molecular weight 470 kDa with three long glycosaminoglycan (GAG) chains attached, each approximately 70-100 kDa. The GAG chains of HSPG2 bind growth factors in the ECM, and serve as co-ligands or ligand enhancers when bound to receptors. MMP14 and MMP15 (MT1-MMP and MT2-MMP) can degrade HSPG2 (d'Ortho et al. 1997).
Literature References
PubMed ID Title Journal Year
9461298 Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases

d'Ortho, MP, Will, H, Atkinson, S, Butler, G, Messent, A, Gavrilovic, J, Smith, B, Timpl, R, Zardi, L, Murphy, G

Eur J Biochem 1997
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Catalyst Activity

metalloendopeptidase activity of MMP14, MMP15 [plasma membrane]

Physical Entity
MMP14, MMP15 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
HSPG2 (perlecan) degradation by MMP14, MMP15 (Caenorhabditis elegans)
HSPG2 (perlecan) degradation by MMP14, MMP15 (Drosophila melanogaster)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-24)
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