HSPG2 protein (perlecan) consists of a core protein of molecular weight 470 kDa with three long glycosaminoglycan (GAG) chains attached, each approximately 70-100 kDa. The GAG chains of HSPG2 bind growth factors in the ECM, and serve as co-ligands or ligand enhancers when bound to receptors. MMP14 and MMP15 (MT1-MMP and MT2-MMP) can degrade HSPG2 (d'Ortho et al. 1997).
Gavrilovic, J, Messent, A, Smith, B, Butler, G, Zardi, L, d'Ortho, MP, Murphy, G, Will, H, Timpl, R, Atkinson, S
metalloendopeptidase activity of MMP14, MMP15 [plasma membrane]
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