HSPG2 (perlecan) degradation by MMP13, CTSS

Stable Identifier
R-HSA-2534160
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Degradation of perlecan by MMP13, CTSS
ReviewStatus
5/5
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HSPG2 (perlecan) degradation by MMP13, CTSS
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The GAG chains of HSPG2 bind growth factors in the ECM, and serve as co-ligands or ligand enhancers when bound to receptors. For example, HS-bound FGF was released from cultured cells by treatments with MMP3, rat MMP13, and plasmin (Whitelock et al. 1996). The core protein of HSPG2 can be cleaved by cathepsin S (Liuzzo et al. 1999).
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Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of MMP13, CTSS [extracellular region]

Physical Entity
MMP13, CTSS [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Degradation of HSPG2 by Mmp13 and Ctss (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-24)
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