Unknown NAT N-acylates Gly in GNAT1

Stable Identifier
R-HSA-2534040
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
Unknown N-acyltransferase N-acylates glycine residue in GNAT1
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After removal of the N-terminal methionine (Met) residue, an unknown N-acyltransferase, similar to the enzymes glycylpeptide N-tetradecanoyltransferase 1 and 2 (NMT1 and 2), mediates the transfer of acyl groups from acyl-CoA to the now N-terminal glycine (Gly) residue of transducin's alpha subunit (GNAT1). The fatty acyl groups transferred are lauroyl (C12:0) and unsaturated myristoyl groups (C14:2 and C14:1). Myristoylation is thought to aid enzyme function and localization. This human event is inferred from bovine experiments demonstrating this activity (Kokame et al 1992).

Literature References
PubMed ID Title Journal Year
1436039 Lipid modification at the N terminus of photoreceptor G-protein alpha-subunit

Kokame, K, Fukada, Y, Yoshizawa, T, Takao, T, Shimonishi, Y

Nature 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycine N-acyltransferase activity of unknown NAT [cytosol]
Physical Entity
Activity
Inferred From
Authored
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Created
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