Reactome | HIRA [nucleoplasm]

HIRA [nucleoplasm]

Stable Identifier

R-HSA-2532790

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein HIRA

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P54198 HIRA

Gene Names

HIRA, DGCR1, HIR, TUPLE1

Chain

chain:1-1017

Reference Genes

BioGPS Gene:7290 HIRA

COSMIC - genes:HIRA HIRA

CTD Gene:7290 HIRA

dbSNP Gene:7290 HIRA

ENSEMBL:ENSG00000100084 HIRA

HGNC:4916 HIRA

KEGG:hsa:7290 HIRA

Monarch:7290 HIRA

NCBI Gene:7290 HIRA

OMIM:600237 HIRA

UCSC:P54198 HIRA

Reference Transcript

RefSeq:NM_003325.3 HIRA

Other Identifiers

11720837_a_at

11751996_a_at

11752104_a_at

16932261

217427_PM_s_at

217427_s_at

32706_at

3952639

3952640

3952647

3952650

3952651

3952653

3952655

3952656

3952657

3952658

3952659

3952662

3952664

3952668

3952671

3952672

3952673

3952674

3952675

3952676

3952677

3952678

3952683

3952684

3952689

3952690

3952693

3952696

3952697

3952698

3952712

3952713

7290

8074432

A_23_P154938

GE60125

GO:0000417

GO:0000785

GO:0001649

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006334

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0007369

GO:0009653

GO:0016605

GO:0030154

GO:0031491

GO:0032991

GO:0042393

GO:0042692

GO:0045892

GO:0061629

GO:0065003

GO:0070062

HMNXSV003047684

HMNXSV003054366

Hs.172350.1.S1_3p_a_at

ILMN_1813664

PH_hs_0025021

TC22000495.hg

Participates

as an output of

HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA (Homo sapiens)

as a component of

as an input of

Inferred To

Hira [nucleoplasm] (Drosophila melanogaster)

Hira [nucleoplasm] (Mus musculus)

Hira [nucleoplasm] (Rattus norvegicus)

hip1 [nucleoplasm] (Schizosaccharomyces pombe)

HIR1 [nucleoplasm] (Saccharomyces cerevisiae)

hira-1 [nucleoplasm] (Caenorhabditis elegans)

hira [nucleoplasm] (Dictyostelium discoideum)

hira [nucleoplasm] (Xenopus tropicalis)

HIRA [nucleoplasm] (Bos taurus)

HIRA [nucleoplasm] (Canis familiaris)

HIRA [nucleoplasm] (Gallus gallus)

HIRA [nucleoplasm] (Plasmodium falciparum)

HIRA [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_003316.3

ENSEMBL

ENSP00000345350, ENST00000340170, ENSP00000263208, ENSG00000100084, ENST00000263208

OpenTargets

ENSG00000100084

GeneCards

HIRA

HPA

ENSG00000100084-HIRA

PRO

P54198

Pharos - Targets

P54198

GlyGen

P54198

Orphanet

HIRA

PDB

5YJE, 2I32

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.902	16
UniProt:Q9NVP2 ASF1B			0.826	7
UniProt:Q9NPG3 UBN1	1	UBN1 [nucleoplasm] (R-HSA-2532791)	0.711	11
UniProt:P84243 H3-3A	20	Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206) H3F3A [nucleoplasm] (R-HSA-212295) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) Cit-R3,R9,R18,R27-H3F3A [extracellular region] (R-HSA-9855664) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) H3F3A [extracellular region] (R-HSA-977567) acK H3F3A [nucleoplasm] (R-HSA-9943919) H3R17me2a [nucleoplasm] (R-HSA-9822613) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) MeK-H3F3A [nucleoplasm] (R-HSA-427369) Me1K5-H3-3A [nucleoplasm] (R-HSA-9864864) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504)	0.643	3
UniProt:Q6ZU65 UBN2			0.564	2
UniProt:Q96DT7 ZBT10			0.527	2
UniProt:O95196 CSPG5	20	CSE-CSPG5 [lysosomal lumen] (R-HSA-2065117) C6S-CSPG5 [lysosomal lumen] (R-HSA-2065073) C4S-CSPG5 [lysosomal lumen] (R-HSA-2065088) D2,4(S)2-CSPG5 [lysosomal lumen] (R-HSA-2065264) D4S-CSPG5 [lysosomal lumen] (R-HSA-2065243) CSPG5 [Golgi lumen] (R-HSA-2063980) XylS-CSPG5 [Golgi lumen] (R-HSA-2064153) Gal-Xyl-CSPG5 [Golgi lumen] (R-HSA-2064011) Gal-Gal-Xyl-CSPG5 [Golgi lumen] (R-HSA-2064223) GlcA-Gal-Gal-Xyl-CSPG5 [Golgi lumen] (R-HSA-2064033) GlcA-Gal-Gal-XylP-CSPG5 [Golgi lumen] (R-HSA-9941336) chondroitin(1)-CSPG5 [Golgi lumen] (R-HSA-2064071) chondroitin(2)-CSPG5 [Golgi lumen] (R-HSA-2063984) chondroitin(3)-CSPG5 [Golgi lumen] (R-HSA-2064164) C4S-CSPG5 [Golgi lumen] (R-HSA-2064000) D4S-CSPG5 [Golgi lumen] (R-HSA-2065137) dermatan-CSPG5 [Golgi lumen] (R-HSA-5607521) D2,4(S)2-CSPG5 [Golgi lumen] (R-HSA-2065121) D2,4,4(S)3-CSPG5 [Golgi lumen] (R-HSA-2065100) D4,6S-CSPG5 [Golgi lumen] (R-HSA-9941360)	0.527	3

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