Reactome | FCN1 [extracellular region]

FCN1 [extracellular region]

Stable Identifier

R-HSA-2530451

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

ficolin-1, M-ficolin

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        FCN1 dodecamer [extracellular region] (Homo sapiens)
        
        FCN1 trimer [extracellular region] (Homo sapiens)
        
        FCN1 [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        FCN1 dodecamer [extracellular region] (Homo sapiens)
        
        FCN1 trimer [extracellular region] (Homo sapiens)
        
        FCN1 [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        Activation of MASPs (Homo sapiens)
        
        MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
        
        FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        FCN1 dodecamer [extracellular region] (Homo sapiens)
        
        FCN1 trimer [extracellular region] (Homo sapiens)
        
        FCN1 [extracellular region] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        FCN1 dodecamer [extracellular region] (Homo sapiens)
        
        FCN1 trimer [extracellular region] (Homo sapiens)
        
        FCN1 [extracellular region] (Homo sapiens)
        
        Ficolins bind to repetitive carbohydrate structures on the target cell surface (Homo sapiens)
        
        Ficolin-1 binds to molecular patterns on the target cell surface (Homo sapiens)
        
        FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        FCN1 dodecamer [extracellular region] (Homo sapiens)
        
        FCN1 trimer [extracellular region] (Homo sapiens)
        
        FCN1 [extracellular region] (Homo sapiens)
        
        FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
        
        FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        FCN1 dodecamer [extracellular region] (Homo sapiens)
        
        FCN1 trimer [extracellular region] (Homo sapiens)
        
        FCN1 [extracellular region] (Homo sapiens)
  - Neutrophil degranulation (Homo sapiens)
    - Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
      - Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
        
        FCN1 [extracellular region] (Homo sapiens)
    - Exocytosis of secretory granule lumen proteins (Homo sapiens)
      - Secretory granule lumen proteins [extracellular region] (Homo sapiens)
        
        FCN1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00602 FCN1

Gene Names

FCN1, FCNM

Chain

signal peptide:1-29, chain:30-326

Reference Genes

BioGPS Gene:2219 FCN1

COSMIC (genes):FCN1 FCN1

CTD Gene:2219 FCN1

dbSNP Gene:2219 FCN1

ENSEMBL:ENSG00000085265 FCN1

HGNC:3623 FCN1

KEGG:hsa:2219 FCN1

Monarch:2219 FCN1

NCBI Gene:2219 FCN1

OMIM:601252 FCN1

UCSC:O00602 FCN1

Reference Transcript

RefSeq:NM_002003.4 FCN1

Participates

as a member of

as a component of

FCN1 trimer [extracellular region] (Homo sapiens)

Other forms of this molecule

FCN1 [secretory granule lumen]

FCN1 [ficolin-1-rich granule lumen]

Inferred To

FCN2 [extracellular region] (Canis familiaris)

FCN2 [extracellular region] (Sus scrofa)

LOC105947509 [extracellular region] (Xenopus tropicalis)

LOC116406488 [extracellular region] (Xenopus tropicalis)

MGC107780 [extracellular region] (Xenopus tropicalis)

Homologues of FCN1 [extracellular region] (Mus musculus)

Homologues of FCN1 [extracellular region] (Rattus norvegicus)

Homologues of FCN1 [extracellular region] (Sus scrofa)

Homologues of FCN1 [extracellular region] (Xenopus tropicalis)

FCN1 [extracellular region] (Bos taurus)

FCN1 [extracellular region] (Gallus gallus)

FCN1 [extracellular region] (Mus musculus)

FCN1 [extracellular region] (Rattus norvegicus)

FCN1 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001994.2

ENSEMBL

ENSP00000360871, ENSG00000085265, ENST00000371806

OpenTargets

ENSG00000085265

GeneCards

FCN1

HPA

ENSG00000085265-FCN1

PRO

O00602

Pharos - Targets

O00602

GlyGen

O00602

HMDB Protein

HMDBP14351

PDB

2WNP, 2JHM, 2JHL, 2JHK, 2JHH, 2JHI, 2D39

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.527	2