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FCN1 [extracellular region]
Stable Identifier
R-HSA-2530451
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
ficolin-1, M-ficolin
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Conversion of C2 into C2a and C2b (Homo sapiens)
C4 activators [plasma membrane] (Homo sapiens)
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
FCN1 dodecamer [extracellular region] (Homo sapiens)
FCN1 trimer [extracellular region] (Homo sapiens)
FCN1 [extracellular region] (Homo sapiens)
Conversion of C4 into C4a and C4b (Homo sapiens)
C4 activators [plasma membrane] (Homo sapiens)
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
FCN1 dodecamer [extracellular region] (Homo sapiens)
FCN1 trimer [extracellular region] (Homo sapiens)
FCN1 [extracellular region] (Homo sapiens)
Creation of C4 and C2 activators (Homo sapiens)
Lectin pathway of complement activation (Homo sapiens)
Activation of MASPs (Homo sapiens)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
FCN1 dodecamer [extracellular region] (Homo sapiens)
FCN1 trimer [extracellular region] (Homo sapiens)
FCN1 [extracellular region] (Homo sapiens)
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
FCN1 dodecamer [extracellular region] (Homo sapiens)
FCN1 trimer [extracellular region] (Homo sapiens)
FCN1 [extracellular region] (Homo sapiens)
Ficolins bind to repetitive carbohydrate structures on the target cell surface (Homo sapiens)
Ficolin-1 binds to molecular patterns on the target cell surface (Homo sapiens)
FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
FCN1 dodecamer [extracellular region] (Homo sapiens)
FCN1 trimer [extracellular region] (Homo sapiens)
FCN1 [extracellular region] (Homo sapiens)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
FCN1 dodecamer [extracellular region] (Homo sapiens)
FCN1 trimer [extracellular region] (Homo sapiens)
FCN1 [extracellular region] (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
FCN1 [extracellular region] (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
FCN1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00602 FCN1
Gene Names
FCN1, FCNM
Chain
signal peptide:1-29, chain:30-326
Reference Genes
BioGPS Gene:2219 FCN1
COSMIC (genes):FCN1 FCN1
CTD Gene:2219 FCN1
dbSNP Gene:2219 FCN1
ENSEMBL:ENSG00000085265 FCN1
HGNC:3623 FCN1
KEGG:hsa:2219 FCN1
Monarch:2219 FCN1
NCBI Gene:2219 FCN1
OMIM:601252 FCN1
UCSC:O00602 FCN1
Reference Transcript
RefSeq:NM_002003.4 FCN1
Participates
as a member of
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
as a component of
FCN1 trimer [extracellular region] (Homo sapiens)
Other forms of this molecule
FCN1 [secretory granule lumen]
FCN1 [ficolin-1-rich granule lumen]
Inferred To
FCN2 [extracellular region]
(Canis familiaris)
FCN2 [extracellular region]
(Sus scrofa)
LOC105947509 [extracellular region]
(Xenopus tropicalis)
LOC116406488 [extracellular region]
(Xenopus tropicalis)
MGC107780 [extracellular region]
(Xenopus tropicalis)
Homologues of FCN1 [extracellular region]
(Mus musculus)
Homologues of FCN1 [extracellular region]
(Rattus norvegicus)
Homologues of FCN1 [extracellular region]
(Sus scrofa)
Homologues of FCN1 [extracellular region]
(Xenopus tropicalis)
FCN1 [extracellular region]
(Bos taurus)
FCN1 [extracellular region]
(Gallus gallus)
FCN1 [extracellular region]
(Mus musculus)
FCN1 [extracellular region]
(Rattus norvegicus)
FCN1 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001994.2
ENSEMBL
ENSP00000360871
,
ENSG00000085265
,
ENST00000371806
OpenTargets
ENSG00000085265
GeneCards
FCN1
HPA
ENSG00000085265-FCN1
PRO
O00602
Pharos - Targets
O00602
GlyGen
O00602
HMDB Protein
HMDBP14351
PDB
2WNP
,
2JHM
,
2JHL
,
2JHK
,
2JHH
,
2JHI
,
2D39
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.527
2
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