CD59, the major inhibitor of the complement membrane attack complex, is an 18–20 kDa glycoprotein, linked to the membrane via a glycosylphosphatidylinositol (GPI)-anchor. It interacts with complement components C8 and C9 during assembly of the membrane attack complex (MAC) and inhibits C9 polymerization, thus preventing the formation of MAC [Lehto T and Meri S. 1993;Rollins SA et al 1991]
Christmas, SE, de la Mata Espinosa, CT, Halliday, D, Johnson, PM, Cummerson, JA, Buxton, CA
Morgan, BP, Meri, S, Lehto, T
Abagyan, R, Morgan, BP, Tomlinson, S, Smith, CA, Song, H, Huang, Y
Lehto, T, Meri, S
Fedarovich, A, Davies, C, Tomlinson, S, Huang, Y
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