CD59 inhibits MAC formation

Stable Identifier
R-HSA-2530445
Type
Reaction [binding]
Species
Homo sapiens
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CD59, the major inhibitor of the complement membrane attack complex, is an 18–20 kDa glycoprotein, linked to the membrane via a glycosylphosphatidylinositol (GPI)-anchor. It interacts with complement components C8 and C9 during assembly of the membrane attack complex (MAC) and inhibits C9 polymerization, thus preventing the formation of MAC [Lehto T and Meri S. 1993;Rollins SA et al 1991]

Literature References
PubMed ID Title Journal Year
9038722 Binding of human and rat CD59 to the terminal complement complexes

Lehto, T, Morgan, BP, Meri, S

Immunology 1997
16999828 Levels of expression of complement regulatory proteins CD46, CD55 and CD59 on resting and activated human peripheral blood leucocytes

Christmas, SE, de la Mata Espinosa, CT, Halliday, D, Buxton, CA, Cummerson, JA, Johnson, PM

Immunology 2006
16079145 Insights into the human CD59 complement binding interface toward engineering new therapeutics

Huang, Y, Smith, CA, Song, H, Morgan, BP, Abagyan, R, Tomlinson, S

J. Biol. Chem. 2005
7691959 Interactions of soluble CD59 with the terminal complement complexes. CD59 and C9 compete for a nascent epitope on C8

Lehto, T, Meri, S

J Immunol 1993
17505110 Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex

Huang, Y, Fedarovich, A, Tomlinson, S, Davies, C

Acta Crystallogr D Biol Crystallogr 2007
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