Reactome | CD59 inhibits MAC formation

CD59 inhibits MAC formation

Stable Identifier

R-HSA-2530445

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

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CD59, the major inhibitor of the complement membrane attack complex, is an 18–20 kDa glycoprotein, linked to the membrane via a glycosylphosphatidylinositol (GPI)-anchor. It interacts with complement components C8 and C9 during assembly of the membrane attack complex (MAC) and inhibits C9 polymerization, thus preventing the formation of MAC [Lehto T and Meri S. 1993;Rollins SA et al 1991]

Literature References

PubMed ID	Title	Journal	Year
9038722	Binding of human and rat CD59 to the terminal complement complexes Lehto, T, Morgan, BP, Meri, S	Immunology	1997
16999828	Levels of expression of complement regulatory proteins CD46, CD55 and CD59 on resting and activated human peripheral blood leucocytes Christmas, SE, de la Mata Espinosa, CT, Halliday, D, Buxton, CA, Cummerson, JA, Johnson, PM	Immunology	2006
16079145	Insights into the human CD59 complement binding interface toward engineering new therapeutics Huang, Y, Smith, CA, Song, H, Morgan, BP, Abagyan, R, Tomlinson, S	J. Biol. Chem.	2005
7691959	Interactions of soluble CD59 with the terminal complement complexes. CD59 and C9 compete for a nascent epitope on C8 Lehto, T, Meri, S	J Immunol	1993
17505110	Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex Huang, Y, Fedarovich, A, Tomlinson, S, Davies, C	Acta Crystallogr D Biol Crystallogr	2007