Reactome | FCN3 [extracellular region]

FCN3 [extracellular region]

Stable Identifier

R-HSA-2530443

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

ficolin 3, H-ficolin

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        FCN3 oligomer [extracellular region] (Homo sapiens)
        
        FCN3 trimer [extracellular region] (Homo sapiens)
        
        FCN3 [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        FCN3 oligomer [extracellular region] (Homo sapiens)
        
        FCN3 trimer [extracellular region] (Homo sapiens)
        
        FCN3 [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        Activation of MASPs (Homo sapiens)
        
        MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        FCN3 ligands:FCN3 multimer:MASP1 dimer:MASP2 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
        
        FCN3 oligomer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        FCN3 oligomer [extracellular region] (Homo sapiens)
        
        FCN3 trimer [extracellular region] (Homo sapiens)
        
        FCN3 [extracellular region] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        FCN3 oligomer [extracellular region] (Homo sapiens)
        
        FCN3 trimer [extracellular region] (Homo sapiens)
        
        FCN3 [extracellular region] (Homo sapiens)
        
        Ficolins bind to repetitive carbohydrate structures on the target cell surface (Homo sapiens)
        
        Ficolin-3 binds to molecular patterns on the target cell surface (Homo sapiens)
        
        FCN3 ligands:FCN3 multimer:MASP1 dimer:MASP2 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
        
        FCN3 oligomer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        FCN3 oligomer [extracellular region] (Homo sapiens)
        
        FCN3 trimer [extracellular region] (Homo sapiens)
        
        FCN3 [extracellular region] (Homo sapiens)
        
        FCN3 oligomer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        FCN3 oligomer [extracellular region] (Homo sapiens)
        
        FCN3 trimer [extracellular region] (Homo sapiens)
        
        FCN3 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75636 FCN3

Gene Names

FCN3, FCNH, HAKA1

Chain

signal peptide:1-23, chain:24-299

Reference Genes

BioGPS Gene:8547 FCN3

COSMIC (genes):FCN3 FCN3

CTD Gene:8547 FCN3

dbSNP Gene:8547 FCN3

ENSEMBL:ENSG00000142748 FCN3

ENSEMBL_homo_sapiens_GENE:ENSG00000142748.14 FCN3

HGNC:3625 FCN3

KEGG Gene (Homo sapiens):8547 FCN3

Monarch:8547 FCN3

NCBI Gene:8547 FCN3

OMIM:604973 FCN3

UCSC:O75636 FCN3

Reference Transcript

Other Identifiers

11725215_a_at

11725216_s_at

16684000

205866_PM_at

205866_at

2403081

2403082

2403083

2403085

2403086

2403087

2403088

2403090

2403092

2403093

2403094

34708_at

7914075

8547

A_23_P115246

GE81314

GO:0001867

GO:0002376

GO:0002752

GO:0003823

GO:0005102

GO:0005515

GO:0005576

GO:0005581

GO:0005615

GO:0005886

GO:0006508

GO:0006956

GO:0009897

GO:0016192

GO:0023052

GO:0030246

GO:0030312

GO:0031012

GO:0043654

GO:0045087

GO:0046597

GO:0046872

GO:0051607

GO:0062023

GO:0072562

GO:0097367

GO:0098542

GO:1902679

GO:1903028

GO:1905370

HMNXSV003044737

ILMN_1780060

ILMN_2349771

PH_hs_0016326

TC01002406.hg

g4504330_3p_at

Participates

as a component of

FCN3 trimer [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_775628.1, NP_003656.2

OpenTargets

ENSG00000142748

GeneCards

O75636

HPA

ENSG00000142748-FCN3

Ensembl

ENSG00000142748, ENSP00000347077, ENST00000270879, ENSP00000270879, ENST00000354982

PRO

O75636

Pharos - Targets

O75636

Orphanet

22037

PDB

2J60, 2J5Z, 2J64

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.544	3