Reactome | FCN2 [extracellular region]

FCN2 [extracellular region]

Stable Identifier

R-HSA-2530438

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

L-ficolin, ficolin 2

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        FCN2 dodecamer [extracellular region] (Homo sapiens)
        
        FCN2 trimer [extracellular region] (Homo sapiens)
        
        FCN2 [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        FCN2 dodecamer [extracellular region] (Homo sapiens)
        
        FCN2 trimer [extracellular region] (Homo sapiens)
        
        FCN2 [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        Activation of MASPs (Homo sapiens)
        
        MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
        
        FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        FCN2 dodecamer [extracellular region] (Homo sapiens)
        
        FCN2 trimer [extracellular region] (Homo sapiens)
        
        FCN2 [extracellular region] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        FCN2 dodecamer [extracellular region] (Homo sapiens)
        
        FCN2 trimer [extracellular region] (Homo sapiens)
        
        FCN2 [extracellular region] (Homo sapiens)
        
        Ficolins bind to repetitive carbohydrate structures on the target cell surface (Homo sapiens)
        
        Ficolin-2 binds to molecular patterns on the target cell surface (Homo sapiens)
        
        FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        FCN2 dodecamer [extracellular region] (Homo sapiens)
        
        FCN2 trimer [extracellular region] (Homo sapiens)
        
        FCN2 [extracellular region] (Homo sapiens)
        
        FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
        
        FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        FCN2 dodecamer [extracellular region] (Homo sapiens)
        
        FCN2 trimer [extracellular region] (Homo sapiens)
        
        FCN2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15485 FCN2

Gene Names

FCN2, FCNL

Chain

signal peptide:1-25, chain:26-313

Reference Genes

BioGPS Gene:2220 FCN2

COSMIC (genes):FCN2 FCN2

CTD Gene:2220 FCN2

dbSNP Gene:2220 FCN2

ENSEMBL:ENSG00000160339.16 FCN2

HGNC:3624 FCN2

KEGG Gene (Homo sapiens):2220 FCN2

Monarch:2220 FCN2

NCBI Gene:2220 FCN2

OMIM:601624 FCN2

UCSC:Q15485 FCN2

Reference Transcript

Other Identifiers

11756838_a_at

11759241_a_at

17091030

207804_PM_s_at

207804_s_at

2220

3193635

3193636

3193638

3193640

3193642

3193645

3193646

3193647

3193648

3193649

3229344

3229349

3229357

34602_at

8159211

A_23_P216756

A_23_P501732

D63160_at

GE58613

GO:0001867

GO:0002376

GO:0002752

GO:0003823

GO:0005102

GO:0005515

GO:0005576

GO:0005581

GO:0005615

GO:0005886

GO:0006508

GO:0008228

GO:0009897

GO:0016192

GO:0023052

GO:0030246

GO:0030312

GO:0031012

GO:0043226

GO:0043394

GO:0043654

GO:0045087

GO:0046872

GO:0048306

GO:0050829

GO:0050830

GO:0062023

GO:0070062

GO:0072562

GO:0097367

GO:0098542

GO:1903028

GO:1905370

GO:2001065

HMNXSV003048650

ILMN_1714057

ILMN_1793504

TC09000788.hg

g4758347_3p_a_at

g8051589_3p_x_at

Participates

as a component of

FCN2 trimer [extracellular region] (Homo sapiens)

Inferred To

FCN2 [extracellular region] (Bos taurus)

FCN2 [extracellular region] (Canis familiaris)

FCN2 [extracellular region] (Gallus gallus)

FCN2 [extracellular region] (Mus musculus)

FCN2 [extracellular region] (Rattus norvegicus)

FCN2 [extracellular region] (Sus scrofa)

LOC100496945 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_004099.2, NP_056652.1

OpenTargets

ENSG00000160339

HPA

ENSG00000160339-FCN2

GeneCards

Q15485

Ensembl

ENSP00000291744, ENSG00000160339, ENST00000291744, ENSP00000291741, ENST00000350339

PRO

Q15485

Pharos - Targets

Q15485

HMDB Protein

HMDBP07683

PDB

2J3F, 2J3U, 2J61, 2J2P, 2J0Y, 4NYT, 4R9J, 2J3G, 2J0G, 2J0H, 4R9T, 2J3O, 2J1G

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.558	2

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