Fibrillin-1 degradation by MMP14

Stable Identifier
R-HSA-2514831
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Fibrillin-1 degradation by MMP14
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Fibrillin-1 is the major structural component of microfibrils (Kielty et al. 2005). It can be degraded by the membrane-associated MMP14 (Ashworth et al. 1999).
Literature References
PubMed ID Title Journal Year
10229672 Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling

Ashworth, JL, Murphy, G, Rock, MJ, Sherratt, MJ, Shapiro, SD, Shuttleworth, CA, Kielty, CM

Biochem. J. 1999
Participants
Input
Output
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as an event of
Catalyst Activity

metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]

Physical Entity
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Fibrillin-1 degradation by MMP14 (Bos taurus)
Fibrillin-1 degradation by MMP14 (Caenorhabditis elegans)
Fibrillin-1 degradation by MMP14 (Canis familiaris)
Fibrillin-1 degradation by MMP14 (Danio rerio)
Fibrillin-1 degradation by MMP14 (Gallus gallus)
Fibrillin-1 degradation by MMP14 (Mus musculus)
Fibrillin-1 degradation by MMP14 (Rattus norvegicus)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-10)
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