Fibrillin-1 degradation by MMP14

Stable Identifier
R-HSA-2514831
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Fibrillin-1 is the major structural component of microfibrils (Kielty et al. 2005). It can be degraded by the membrane-associated MMP14 (Ashworth et al. 1999).

Literature References
PubMed ID Title Journal Year
10229672 Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling

Ashworth, JL, Murphy, G, Rock, MJ, Sherratt, MJ, Shapiro, SD, Shuttleworth, CA, Kielty, CM

Biochem. J. 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created