Fibrillin-1 degradation by MMP14

Stable Identifier
R-HSA-2514831
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Fibrillin-1 degradation by MMP14
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Fibrillin-1 is the major structural component of microfibrils (Kielty et al. 2005). It can be degraded by the membrane-associated MMP14 (Ashworth et al. 1999).

Literature References
PubMed ID Title Journal Year
10229672 Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling

Shuttleworth, CA, Murphy, G, Sherratt, MJ, Kielty, CM, Ashworth, JL, Rock, MJ, Shapiro, SD

Biochem. J. 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]

Physical Entity
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Fibrillin-1 degradation by MMP14 (Bos taurus)
Fibrillin-1 degradation by MMP14 (Caenorhabditis elegans)
Fibrillin-1 degradation by MMP14 (Canis familiaris)
Fibrillin-1 degradation by MMP14 (Danio rerio)
Fibrillin-1 degradation by MMP14 (Gallus gallus)
Fibrillin-1 degradation by MMP14 (Mus musculus)
Fibrillin-1 degradation by MMP14 (Rattus norvegicus)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-10)
Cite Us!