Elastin degradation by MMP14

Stable Identifier
R-HSA-2514790
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Elastin degradation by MMP14
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Elastin degradation is regulated by the membrane-associated matrix metalloproteinase MMP14 (Xiong et al. 2009) and associated with aneurisms.
Literature References
PubMed ID Title Journal Year
19010778 Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo

Xiong, W, Knispel, R, Weiss, SJ, MacTaggart, J, Greiner, TC, Baxter, BT

J. Biol. Chem. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]

Physical Entity
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Elastin degradation by MMP14 (Bos taurus)
Elastin degradation by MMP14 (Canis familiaris)
Elastin degradation by MMP14 (Gallus gallus)
Elastin degradation by MMP14 (Mus musculus)
Elastin degradation by MMP14 (Rattus norvegicus)
Elastin degradation by MMP14 (Sus scrofa)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-10)
Cite Us!