Reactome | Fibrillin-1 degradation by MMP3, CTSK, CTSL2

Fibrillin-1 degradation by MMP3, CTSK, CTSL2

Stable Identifier

R-HSA-2514772

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Fibrillin-1 degradation by MMP3, CTSK, CTSL2

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Fibrillin-1 can be degraded by MMP3 (Ashworth et al. 1999) and cathepsins K and L2 (V) (Kirschner et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
10229672	Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling Ashworth, JL, Murphy, G, Rock, MJ, Sherratt, MJ, Shapiro, SD, Shuttleworth, CA, Kielty, CM	Biochem. J.	1999
21784848	Classical and neonatal Marfan syndrome mutations in fibrillin-1 cause differential protease susceptibilities and protein function Kirschner, R, Hubmacher, D, Iyengar, G, Kaur, J, Fagotto-Kaufmann, C, Brömme, D, Bartels, R, Reinhardt, DP	J. Biol. Chem.	2011