Fibrillin-1 degradation by MMP3, CTSK, CTSL2

Stable Identifier
R-HSA-2514772
Type
Reaction
Species
Homo sapiens
Compartment
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Fibrillin-1 can be degraded by MMP3 (Ashworth et al. 1999) and cathepsins K and L2 (V) (Kirschner et al. 2011).

Literature References
PubMed ID Title Journal Year
10229672 Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling

Shuttleworth, CA, Murphy, G, Sherratt, MJ, Kielty, CM, Ashworth, JL, Rock, MJ, Shapiro, SD

Biochem. J. 1999
21784848 Classical and neonatal Marfan syndrome mutations in fibrillin-1 cause differential protease susceptibilities and protein function

Brömme, D, Hubmacher, D, Fagotto-Kaufmann, C, Kaur, J, Iyengar, G, Bartels, R, Kirschner, R, Reinhardt, DP

J. Biol. Chem. 2011
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of MMP3, CTSK, CTSL2 [extracellular region]

Orthologous Events
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