MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The MSR1:ligand complex (SCARA1:ligand, SR-A:ligand) is endocytosed (Matsumoto et al. 1990, Gough et al. 1998, Peiser et al. 2000, Aguilar-Gaytan and Mas-Oliva 2003, Wang and Chandawarkar 2010, Orr et al. 2011). In the cases in which the ligands are located on bacteria or yeast cells the entire cell is phagocytosed (Aguilar-Gaytan and Mas-Oliva 2003, Wang and Chandawarkar 2010). Uptake of modified LDL by macrophages via MSR1 appears to contribute to foam cell formation during atherosclerosis (Matsumoto et al. 1990).
Literature References
PubMed ID Title Journal Year
12763022 Oxidative stress impairs endocytosis of the scavenger receptor class A

Aguilar-Gaytan, R, Mas-Oliva, J

Biochem. Biophys. Res. Commun. 2003
10722588 Macrophage class A scavenger receptor-mediated phagocytosis of Escherichia coli: role of cell heterogeneity, microbial strain, and culture conditions in vitro

Gordon, S, Kodama, T, Peiser, L, Gough, PJ

Infect. Immun. 2000
20849212 Cellular recognition and trafficking of amorphous silica nanoparticles by macrophage scavenger receptor A

Chrisler, WB, Tarasevich, BJ, Thrall, BD, Zangar, RC, Markillie, LM, Tan, R, Orr, GA, Cassens, KJ

Nanotoxicology 2011
2251254 Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions

Ikemoto, S, Kanamori, H, Takaku, F, Itakura, H, Asaoka, H, Aburatani, H, Hayakawa, I, Matsumoto, A, Suzuki, H, Naito, M

Proc. Natl. Acad. Sci. U.S.A. 1990
20888598 Phagocytosis of fungal agents and yeast via macrophage cell surface scavenger receptors

Wang, R, Chandawarkar, RY

J. Surg. Res. 2010
9548586 A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake

Greaves, DR, Gough, PJ, Gordon, S

J Lipid Res 1998
Orthologous Events
Cite Us!