Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
All mammals have three fibrillin genes (Davis & Summers 2012). Fibrillin-3 arose as a duplication of fibrillin-2 that did not occur in the rodent lineage. Fibrillin-1 is the major structural component of microfibrils (Kielty et al. 2005). Fibrillin-2 is expressed earlier in development than fibrillin-1 and may be important for elastic fiber formation (Zhang et al. 1994). Fibrillin-3 was isolated from and is predominantly expressed in brain; it is not known whether it forms microfibrils (Corson et al. 2004). Fibrillin-1 and -2 are degraded by MMP2, 9, 12 and 13 (Ashworth et al. 1999, Hindson et al. 1999). Fibrillin-1 is additionally degraded by MMP3 (Ashworth et al. 1999), the membrane-associated MMP14 (Ashworth et al. 1999), neutrophil elastase (ELANE) (Kielty et al. 1994), cathepsin L2 (V) and cathepsin K (Kirschner et al. 2011).
Literature References
PubMed ID Title Journal Year
10386589 Fibrillin degradation by matrix metalloproteinases: identification of amino- and carboxy-terminal cleavage sites

Shuttleworth, CA, Hindson, VJ, Cunliffe, S, Kielty, CM, Ashworth, JL, Rock, MJ

FEBS Lett. 1999
10229672 Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling

Shuttleworth, CA, Murphy, G, Sherratt, MJ, Kielty, CM, Ashworth, JL, Rock, MJ, Shapiro, SD

Biochem. J. 1999
Catalyst Activity

metalloendopeptidase activity of MMP2,9,12,13 [extracellular region]

Orthologous Events
Cite Us!