Collagen type XIII binds Integrin alpha1beta1

Stable Identifier
R-HSA-2484965
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Collagen type XIII binds Integrin alpha1beta1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Integrin alpha1beta1 is a negative feedback regulator of collagen synthesis (Gardner et al. 1999). CHO cells expressing human integrin alpha1beta1, but not cells expressing integrin alpha2beta1, were able to bind recombinant human collagen type XIII, promoting cell spreading (Nykvist et al. 2000).

Literature References
PubMed ID Title Journal Year
10713152 Distinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagen

Nykvist, P, Tu, H, Ivaska, J, Käpylä, J, Pihlajaniemi, T, Heino, J

J Biol Chem 2000
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Collagen type XIII binds Integrin alpha1beta1 (Canis familiaris)
Collagen type XIII binds Integrin alpha1beta1 (Danio rerio)
Collagen type XIII binds Integrin alpha1beta1 (Drosophila melanogaster)
Collagen type XIII binds Integrin alpha1beta1 (Mus musculus)
Collagen type XIII binds Integrin alpha1beta1 (Rattus norvegicus)
Collagen type XIII binds Integrin alpha1beta1 (Xenopus tropicalis)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-09-27)
Cite Us!