Cleaved collagen type XXV [plasma membrane]

Stable Identifier
R-HSA-2473532
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
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General
COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC (collagenous Alzheimer amyloid plaque component), a soluble form of COL25A1 containing the extracellular collagen domains. CLAC associates with amyloid beta peptides (Abeta) in the brains of patients with Alzheimer's disease, inhibiting amyloid fibril formation (Osada et al. 2005).
Participants
components
Participates
as an output of
Inferred To
Cleaved collagen type XXV [plasma membrane] (Canis familiaris)
Cleaved collagen type XXV [plasma membrane] (Gallus gallus)
Cleaved collagen type XXV [plasma membrane] (Mus musculus)
Cleaved collagen type XXV [plasma membrane] (Rattus norvegicus)
Cleaved collagen type XXV [plasma membrane] (Sus scrofa)
Cleaved collagen type XXV [plasma membrane] (Xenopus tropicalis)
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