FSTL3 binds Activin

Stable Identifier
Reaction [binding]
Homo sapiens
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Two molecules of FSTL3 bind an Activin dimer (Sidis et al. 2002, Stamler et al. 2008). FSTL3 has been experimentally shown to bind Activin A and Activin B (Schneyer et al. 2003). Binding of FSTL3 to Activin AB is inferred. A portion of FSTL3 is also located in the nucleus (Tortoriello et al. 2001), however FSTL3:Activin complexes have not been demonstrated in the nucleus.

Literature References
PubMed ID Title Journal Year
18768470 The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity

Schneyer, A, Kattamuri, C, Keutmann, HT, Stamler, R, Sidis, Y, Thompson, TB

J. Biol. Chem. 2008
12697670 Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG)

Schoen, A, Schneyer, A, Quigg, A, Sidis, Y

Endocrinology 2003
11956142 Follistatin-related protein and follistatin differentially neutralize endogenous vs. exogenous activin

Holmes, WE, Schneyer, AL, Pan, Y, Tortoriello, DV, Keutmann, HT, Sidis, Y

Endocrinology 2002
11459787 Human follistatin-related protein: a structural homologue of follistatin with nuclear localization

Holmes, WE, Tortoriello, DV, Holtzman, DA, Schneyer, AL, Sidis, Y

Endocrinology 2001
Orthologous Events
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