Reactome | FSTL3 binds Activin

FSTL3 binds Activin

Stable Identifier

R-HSA-2473186

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Two molecules of FSTL3 bind an Activin dimer (Sidis et al. 2002, Stamler et al. 2008). FSTL3 has been experimentally shown to bind Activin A and Activin B (Schneyer et al. 2003). Binding of FSTL3 to Activin AB is inferred. A portion of FSTL3 is also located in the nucleus (Tortoriello et al. 2001), however FSTL3:Activin complexes have not been demonstrated in the nucleus.

Literature References

PubMed ID	Title	Journal	Year
18768470	The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity Stamler, R, Keutmann, HT, Sidis, Y, Kattamuri, C, Schneyer, A, Thompson, TB	J. Biol. Chem.	2008
12697670	Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG) Schneyer, A, Schoen, A, Quigg, A, Sidis, Y	Endocrinology	2003
11956142	Follistatin-related protein and follistatin differentially neutralize endogenous vs. exogenous activin Sidis, Y, Tortoriello, DV, Holmes, WE, Pan, Y, Keutmann, HT, Schneyer, AL	Endocrinology	2002
11459787	Human follistatin-related protein: a structural homologue of follistatin with nuclear localization Tortoriello, DV, Sidis, Y, Holtzman, DA, Holmes, WE, Schneyer, AL	Endocrinology	2001