FSTL3 binds Activin

Stable Identifier
R-HSA-2473186
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Two molecules of FSTL3 bind an Activin dimer (Sidis et al. 2002, Stamler et al. 2008). FSTL3 has been experimentally shown to bind Activin A and Activin B (Schneyer et al. 2003). Binding of FSTL3 to Activin AB is inferred. A portion of FSTL3 is also located in the nucleus (Tortoriello et al. 2001), however FSTL3:Activin complexes have not been demonstrated in the nucleus.

Literature References
PubMed ID Title Journal Year
12697670 Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG)

Schneyer, A, Schoen, A, Quigg, A, Sidis, Y

Endocrinology 2003
18768470 The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity

Stamler, R, Keutmann, HT, Sidis, Y, Kattamuri, C, Schneyer, A, Thompson, TB

J. Biol. Chem. 2008
11956142 Follistatin-related protein and follistatin differentially neutralize endogenous vs. exogenous activin

Sidis, Y, Tortoriello, DV, Holmes, WE, Pan, Y, Keutmann, HT, Schneyer, AL

Endocrinology 2002
11459787 Human follistatin-related protein: a structural homologue of follistatin with nuclear localization

Tortoriello, DV, Sidis, Y, Holtzman, DA, Holmes, WE, Schneyer, AL

Endocrinology 2001
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!