Follistatin (FST) binds Activin

Stable Identifier
Reaction [binding]
Homo sapiens
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Two molecules of Follistatin (FST) bind an Activin dimer in serum or follicular fluid (Schneyer et al. 1992, Krummen et al. 1993, Schneyer et al. 1994, Thompson et al. 2005). FST has been experimentally shown to bind Activin A and Activin B (Schneyer et al. 2003). Binding of FST to Activin AB is inferred.
Literature References
PubMed ID Title Journal Year
8033815 Characterization of unique binding kinetics of follistatin and activin or inhibin in serum

Rzucidlo, DA, Sluss, PM, Crowley, WF, Schneyer, AL

Endocrinology 1994
12697670 Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG)

Schoen, A, Schneyer, A, Quigg, A, Sidis, Y

Endocrinology 2003
16198295 The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding

Woodruff, TK, Jardetzky, TS, Lerch, TF, Cook, RW, Thompson, TB

Dev Cell 2005
7678220 Identification and characterization of binding proteins for inhibin and activin in human serum and follicular fluids

Mather, JP, Baly, DL, Cox, ET, Mann, E, Woodruff, TK, Garg, S, DeGuzman, G, Wong, WL, Krummen, LA, Cossum, P

Endocrinology 1993
1592877 Activin-binding proteins in human serum and follicular fluid

O'Neil, DA, Crowley, WF, Schneyer, AL

J. Clin. Endocrinol. Metab. 1992
Orthologous Events
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