Follistatin (FST) binds Activin

Stable Identifier
R-HSA-2473184
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Two molecules of Follistatin (FST) bind an Activin dimer in serum or follicular fluid (Schneyer et al. 1992, Krummen et al. 1993, Schneyer et al. 1994, Thompson et al. 2005). FST has been experimentally shown to bind Activin A and Activin B (Schneyer et al. 2003). Binding of FST to Activin AB is inferred.

Literature References
PubMed ID Title Journal Year
12697670 Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG)

Schneyer, A, Schoen, A, Quigg, A, Sidis, Y

Endocrinology 2003
8033815 Characterization of unique binding kinetics of follistatin and activin or inhibin in serum

Schneyer, AL, Rzucidlo, DA, Sluss, PM, Crowley, WF

Endocrinology 1994
16198295 The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding

Thompson, TB, Lerch, TF, Cook, RW, Woodruff, TK, Jardetzky, TS

Dev Cell 2005
7678220 Identification and characterization of binding proteins for inhibin and activin in human serum and follicular fluids

Krummen, LA, Woodruff, TK, DeGuzman, G, Cox, ET, Baly, DL, Mann, E, Garg, S, Wong, WL, Cossum, P, Mather, JP

Endocrinology 1993
1592877 Activin-binding proteins in human serum and follicular fluid

Schneyer, AL, O'Neil, DA, Crowley, WF

J. Clin. Endocrinol. Metab. 1992
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!