Reactome | Follistatin (FST) binds Activin

Follistatin (FST) binds Activin

Stable Identifier

R-HSA-2473184

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Two molecules of Follistatin (FST) bind an Activin dimer in serum or follicular fluid (Schneyer et al. 1992, Krummen et al. 1993, Schneyer et al. 1994, Thompson et al. 2005). FST has been experimentally shown to bind Activin A and Activin B (Schneyer et al. 2003). Binding of FST to Activin AB is inferred.

Literature References

PubMed ID	Title	Journal	Year
8033815	Characterization of unique binding kinetics of follistatin and activin or inhibin in serum Rzucidlo, DA, Sluss, PM, Crowley, WF, Schneyer, AL	Endocrinology	1994
12697670	Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG) Schoen, A, Schneyer, A, Quigg, A, Sidis, Y	Endocrinology	2003
16198295	The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding Woodruff, TK, Jardetzky, TS, Lerch, TF, Cook, RW, Thompson, TB	Dev Cell	2005
7678220	Identification and characterization of binding proteins for inhibin and activin in human serum and follicular fluids Mather, JP, Baly, DL, Cox, ET, Mann, E, Woodruff, TK, Garg, S, DeGuzman, G, Wong, WL, Krummen, LA, Cossum, P	Endocrinology	1993
1592877	Activin-binding proteins in human serum and follicular fluid O'Neil, DA, Crowley, WF, Schneyer, AL	J. Clin. Endocrinol. Metab.	1992