CDCA5 (Sororin) enables cohesion of sister centromeres

Stable Identifier
R-HSA-2473151
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm, chromosome, centromeric region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CDCA5 (Sororin) enables cohesion of sister centromeres
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CDCA5 (Sororin) is essential for the establishment of sister chromatid cohesion at centromeres. Experiments in which a recombinant tagged mouse CDCA5 was expressed in human HeLa cell line showed that CDCA5 starts to accumulate on chromatin in S-phase and dissociates from centromeres in anaphase (Nishiyama et al. 2010).

Literature References
PubMed ID Title Journal Year
21111234 Sororin mediates sister chromatid cohesion by antagonizing Wapl

Kreidl, E, Ladurner, R, Hyman, AA, Peters, JM, Bando, M, Mechtler, K, Bhaskara, V, Schleiffer, A, Schmitz, J, Nishiyama, T, Shirahige, K

Cell 2010
Participants
Input
Output
Participates
as an event of
Orthologous Events
CDCA5 (Sororin) enables cohesion of sister centromeres (Bos taurus)
CDCA5 (Sororin) enables cohesion of sister centromeres (Canis familiaris)
CDCA5 (Sororin) enables cohesion of sister centromeres (Danio rerio)
CDCA5 (Sororin) enables cohesion of sister centromeres (Mus musculus)
CDCA5 (Sororin) enables cohesion of sister centromeres (Rattus norvegicus)
CDCA5 (Sororin) enables cohesion of sister centromeres (Sus scrofa)
CDCA5 (Sororin) enables cohesion of sister centromeres (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-10-02)
Reviewed
Zhang, N  (2012-10-22)
Watanabe, Y  (2012-11-20)
Tanno, Y  (2012-11-20)
Created
Orlic-Milacic, M  (2012-09-21)
Cite Us!