Collagen type XXV ectomain shedding

Stable Identifier
R-HSA-2471842
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Identified as a component of amyloid plaques in Alzheimer's brain, the ectodomain of type XXV collagen (known as CLAC) is released by furin convertase activity (Hashimoto et al. 2002). The presence of CLAC leads to Abeta fibril bundles that have an increased resistance to proteases (Söderberg et al. 2005).
Literature References
PubMed ID Title Journal Year
11927537 CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV

Nakamura, A, Iwatsubo, T, Wakabayashi, T, Watanabe, A, Takio, K, Kanazawa, I, Kowa, H, Arai, T, Hosoda, R, Hashimoto, T, Mann, DM

EMBO J. 2002
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of FURIN [plasma membrane]

Orthologous Events
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