Reactome | 5Hyl-COL6A2(?-1019) [extracellular region]

5Hyl-COL6A2(?-1019) [extracellular region]

Stable Identifier

R-HSA-2470156

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

5-hydroxylysyl collagen alpha-2(VI) chain C-term fragment

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Homo sapiens)

- Degradation of the extracellular matrix (Homo sapiens)
  - Collagen degradation (Homo sapiens)
    - Collagen type VI degradation by MMP2,9,11 (Homo sapiens)
      - Cleaved collagen type VI fibril [extracellular region] (Homo sapiens)
        
        Cleaved tropocollagen type VI tetramer [extracellular region] (Homo sapiens)
        
        Cleaved tropocollagen type VI dimer [extracellular region] (Homo sapiens)
        
        Cleaved tropocollagen type VI [extracellular region] (Homo sapiens)
        
        Cleaved collagen alpha-2(VI) chains [extracellular region] (Homo sapiens)
        
        5Hyl-COL6A2(?-1019) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P12110 COL6A2

Gene Names

COL6A2

Chain

signal peptide:1-20, chain:21-1019

Reference Genes

BioGPS Gene:1292 COL6A2

COSMIC (genes):COL6A2 COL6A2

CTD Gene:1292 COL6A2

dbSNP Gene:1292 COL6A2

ENSEMBL:ENSG00000142173 COL6A2

ENSEMBL_homo_sapiens_GENE:ENSG00000142173.17 COL6A2

HGNC:2212 COL6A2

KEGG Gene (Homo sapiens):1292 COL6A2

Monarch:1292 COL6A2

NCBI Gene:1292 COL6A2

OMIM:120240 COL6A2

UCSC:P12110 COL6A2

Reference Transcript

Other Identifiers

11720365_a_at

11744348_x_at

11758832_at

11758833_x_at

1292

16923890

209156_3p_s_at

209156_PM_s_at

209156_s_at

213290_PM_at

213290_at

32098_at

34802_at

3924435

3924439

3924440

3924441

3924443

3924444

3924445

3924446

3924447

3924448

3924450

3924451

3924452

3924453

3924454

3924456

3924457

3924458

3924460

3924461

3924462

3924463

3924464

3924466

3924468

3924469

3924470

3924471

3924475

3924476

3924477

3924478

3924479

3924480

3924481

3924487

3924488

3924489

3924490

3924491

3924492

3924493

3924494

3924495

8069301

A_23_P211233

A_23_P310956

A_33_P3269539

GE56382

GO:0005198

GO:0005515

GO:0005518

GO:0005576

GO:0005581

GO:0005615

GO:0005783

GO:0005788

GO:0005886

GO:0007155

GO:0009411

GO:0009749

GO:0012501

GO:0016020

GO:0023052

GO:0030020

GO:0030312

GO:0031012

GO:0032991

GO:0042383

GO:0043226

GO:0043491

GO:0051402

GO:0062023

GO:0070062

GO:1903561

HMNXSV003031888

Hs.159263.2.S1_3p_at

ILMN_1765017

ILMN_1783909

ILMN_1809928

M20777_at

PH_hs_0019710

PH_hs_0035939

TC21000253.hg

X15882_at

g13603393_3p_a_at

Participates

as a member of

Cleaved collagen alpha-2(VI) chains [extracellular region] (Homo sapiens)

Other forms of this molecule

3x4Hyp-3Hyp-GalHyl-COL6A2(257-1019) [endoplasmic reticulum lumen]

3x4Hyp-GalHyl-COL6A2 [endoplasmic reticulum lumen]

GalHyl-COL6A2 [endoplasmic reticulum lumen]

GlcGalHyl-COL6A2 [endoplasmic reticulum lumen]

3x4Hyp-GlcGalHyl-COL6A2 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GlcGalHyl-COL6A2 [endoplasmic reticulum lumen]

COL6A2 [endoplasmic reticulum lumen]

3x4Hyp-COL6A2 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-COL6A2 [endoplasmic reticulum lumen]

3x4Hyp-5Hyl-COL6A2 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-5Hyl-COL6A2 [endoplasmic reticulum lumen]

5Hyl-COL6A2 [endoplasmic reticulum lumen]

GlcGalHyl-COL6A2(?-1019) [extracellular region]

3x4Hyp-GalHyl-COL6A2(21-?) [extracellular region]

COL6A2(?-1019) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL6A2(21-?) [extracellular region]

3x4Hyp-5Hyl-COL6A2(21-?) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL6A2(?-1019) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL6A2(21-?) [extracellular region]

COL6A2(21-?) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL6A2(?-1019) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL6A2(?-1019) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL6A2(21-?) [extracellular region]

3x4Hyp-GlcGalHyl-COL6A2(?-1019) [extracellular region]

3x4Hyp-3Hyp-COL6A2(21-?) [extracellular region]

3x4Hyp-COL6A2(21-?) [extracellular region]

3x4Hyp-COL6A2(?-1019) [extracellular region]

5Hyl-COL6A2(21-?) [extracellular region]

3x4Hyp-5Hyl-COL6A2(?-1019) [extracellular region]

GlcGalHyl-COL6A2(21-?) [extracellular region]

3x4Hyp-GlcGalHyl-COL6A2(21-?) [extracellular region]

3x4Hyp-GalHyl-COL6A2(?-1019) [extracellular region]

GalHyl-COL6A2(21-?) [extracellular region]

GalHyl-COL6A2(?-1019) [extracellular region]

3x4Hyp-3Hyp-COL6A2(?-1019) [extracellular region]

GlcGalHyl-COL6A2 [extracellular region]

3x4Hyp-GlcGalHyl-COL6A2 [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL6A2 [extracellular region]

COL6A2 [extracellular region]

3x4Hyp-GalHyl-COL6A2 [extracellular region]

3x4Hyp-5Hyl-COL6A2 [extracellular region]

3x4Hyp-COL6A2 [extracellular region]

GalHyl-COL6A2 [extracellular region]

3x4Hyp-3Hyp-COL6A2 [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL6A2 [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL6A2 [extracellular region]

5Hyl-COL6A2 [extracellular region]

Inferred To

Col6a2 [extracellular region] (Mus musculus)

COL6A2 [extracellular region] (Bos taurus)

COL6A2 [extracellular region] (Sus scrofa)

5Hyl-COL6A2(?-1019) [extracellular region] (Caenorhabditis elegans)

5Hyl-COL6A2(?-1019) [extracellular region] (Dictyostelium discoideum)

Modified Residues

Name

(2S,5R)-5-hydroxylysine at unknown position

PsiMod Name

(2S,5R)-5-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.

Cross References

RefSeq

NP_478054.2, NP_478055.2, NP_001840.3, XP_011527753.1

OpenTargets

ENSG00000142173

GeneCards

P12110

HPA

ENSG00000142173-COL6A2

Ensembl

ENST00000397763, ENST00000409416, ENST00000300527, ENSP00000387115, ENSP00000380870, ENSG00000142173, ENSP00000300527

PRO

P12110

Pharos - Targets

P12110

Orphanet

15779

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14780 MMP9	8	MMP9 [ficolin-1-rich granule lumen] (R-HSA-6800973) MMP9 [tertiary granule lumen] (R-HSA-6800181) MMP9(60-106) [extracellular region] (R-HSA-1604699) MMP9(60-707) [extracellular region] (R-HSA-1604726) MMP9(20-59) [extracellular region] (R-HSA-1604685) MMP9(20-106) [extracellular region] (R-HSA-1604713) MMP9(20-707) [extracellular region] (R-HSA-1604376) MMP9(107-707) [extracellular region] (R-HSA-668812)	0.527	2
UniProt:P08253 MMP2	5	MMP2(67-109) [extracellular region] (R-HSA-1604371) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(110-660) [extracellular region] (R-HSA-381456)	0.527	2

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