Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2

Stable Identifier
Reaction [transition]
Homo sapiens
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Acetyltransferases ESCO1 and ESCO2 are homologs of the S. cerevisiae acetyltransferase Eco1, essential for viability in yeast. ESCO1 and ESCO2 share sequence homology in the C-terminal region, consisting of a H2C2 zinc finger motif and an acetyltransferase domain (Hou and Zou 2005). Both ESCO1 and ESCO2 acetylate the cohesin subunit SMC3 on two lysine residues, K105 and K106 (Zhang et al. 2008), an important step in the establishment of sister-chromatid cohesion during the S-phase of the cell cycle. These dual acetylations on SMC3 are deacetylated by HDAC8 after the cohesin removal from chromatin for the dissociation and recycling of cohesin subunits (Deardorff et al. 2012). ESCO1 and ESCO2 differ in their N-termini, which are necessary for chromatin binding, and may perform distinct functions in sister chromatid cohesion (Hou and Zou 2005), as suggested by the study of Esco2 knockout mice (Whelan et al. 2012).

Literature References
PubMed ID Title Journal Year
15958495 Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion

Zou, H, Hou, F

Mol. Biol. Cell 2005
22885700 HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

Shirahige, K, Kiyono, T, Magnaghi-Jaulin, L, Clark, D, Katou, Y, Krantz, ID, Kaiser, FJ, Takagaki, K, Ernst, S, Nozaki, N, Siu, VM, Prigent, C, Christianson, DW, De Baere, E, Decroos, C, Francey, LJ, Di Donato, N, Bando, M, Saitoh, K, Kaur, M, Hirashima, K, Itoh, T, Suzuki, Y, Nakato, R, Mortier, GR, Seimiya, H, Wilde, JJ, Gillessen-Kaesbach, G, Jackson, LG, Watrin, E, Gyftodimou, Y, Willems, PJ, Lombardi, PM, Petersen, MB, Deardorff, MA, Ishikawa, Y, Minamino, M, Jaulin, C, Cole, KE, Hirota, T, Komata, M, Hullings, M

Nature 2012
22101327 Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin

Kreidl, E, Wutz, G, Peters, JM, Egner, A, Whelan, G, Eichele, G

EMBO J. 2012
18614053 Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast

Wang, Y, Zhang, J, Shi, X, Fu, X, Qin, J, Kim, ST, Jia, J, Kim, BJ, Pan, X, Huang, Z, Jung, SY, Li, Y, Zhang, P, Yang, T

Mol. Cell 2008
21111234 Sororin mediates sister chromatid cohesion by antagonizing Wapl

Kreidl, E, Ladurner, R, Hyman, AA, Peters, JM, Bando, M, Mechtler, K, Bhaskara, V, Schleiffer, A, Schmitz, J, Nishiyama, T, Shirahige, K

Cell 2010
Catalyst Activity

N-acetyltransferase activity of ESCO [nucleoplasm]

Orthologous Events
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