Reactome | PTTG1 (Securin) sequesters ESPL1 (Separase)

PTTG1 (Securin) sequesters ESPL1 (Separase)

Stable Identifier

R-HSA-2467798

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Securin sequesters Separase

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        PTTG1 (Securin) sequesters ESPL1 (Separase) (Homo sapiens)

General

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PTTG1 (Securin) sequesters ESPL1 (Separase)

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Up to anaphase onset, ESPL1 (separase i.e. separin) forms a complex with PTTG1 (pituitary tumor-transforming gene 1) i.e. securin. PTTG1 sequesters ESPL1 and block its catalytic site, preventing it from cleaving centromeric cohesin and causing premature separation of sister chromatids (Zou et al. 1999, Waizenegger et al. 2001, Waizenegger et al. 2002). PTTG1 is overexpressed in cancer and acts as an oncogene (Zhang et al. 1999). Regulation of PTTG1 cellular level is important for chromosomal stability in human cells (Jallepalli et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
9892021	Structure, expression, and function of human pituitary tumor-transforming gene (PTTG) Zhang, X, Horwitz, GA, Prezant, TR, Valentini, A, Nakashima, M, Bronstein, MD, Melmed, S	Mol. Endocrinol.	1999
11081627	Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase Waizenegger, IC, Hauf, S, Meinke, A, Peters, JM	Cell	2000
11371342	Securin is required for chromosomal stability in human cells Jallepalli, PV, Waizenegger, IC, Bunz, F, Langer, S, Speicher, MR, Peters, JM, Kinzler, KW, Vogelstein, B, Lengauer, C	Cell	2001
12194817	Regulation of human separase by securin binding and autocleavage Waizenegger, I, Giménez-Abián, JF, Wernic, D, Peters, JM	Curr. Biol.	2002
10411507	Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis Zou, H, McGarry, TJ, Bernal, T, Kirschner, MW	Science	1999