A2E is phagocytosed

Stable Identifier
Reaction [transition]
Homo sapiens
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Early experiments in frog and other species determined that the outer segments of photoreceptors are renewed by phagocytosis and transfer to retinal pigment eplithelial (RPE) cells for processing. A2E, formed in disc membranes of outer segments, is taken along with the phagolysosome (Young 1967, Young & Bok 1969, Katz et al. 1986). Here, for simplicity, only A2E is shown in the phagolysosome.

Literature References
PubMed ID Title Journal Year
6033942 The renewal of photoreceptor cell outer segments

Young, RW

J. Cell Biol. 1967
3792460 Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium

Katz, ML, Drea, CM, Eldred, GE, Hess, HH, Robison, WG

Exp. Eye Res. 1986
5792328 Participation of the retinal pigment epithelium in the rod outer segment renewal process

Young, RW, Bok, D

J. Cell Biol. 1969
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