NRPE condenses with atRAL to form A2PE

Stable Identifier
R-HSA-2466764
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, photoreceptor outer segment membrane
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NRPE condenses with atRAL to form A2PE
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A phosphatidyl-pyridinium bisretinoid compound, A2PE, is formed through condensation of N-retinylidene-PE (NRPE) and a second all-trans-retinol (atRAL) molecule (Parish et al. 1998, Mata et al. 2000). This most likely happens when atRAL is abundant.

Literature References
PubMed ID Title Journal Year
10852960 Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration

Travis, GH, Weng, J, Mata, NL

Proc. Natl. Acad. Sci. U.S.A. 2000
9843937 Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

Hashimoto, M, Parish, CA, Nakanishi, K, Dillon, J, Sparrow, J

Proc. Natl. Acad. Sci. U.S.A. 1998
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Authored
Jassal, B  (2012-09-12)
Reviewed
Blaner, WS  (2013-01-31)
Created
Jassal, B  (2012-09-12)
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