Reactome | BGN binds Collagen types I, VI, (IX)

BGN binds Collagen types I, VI, (IX)

Stable Identifier

R-HSA-2466106

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Biglycan binds Collagen types I, VI, (IX)

ReviewStatus

5/5

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Biglycan is a member of the small leucine-rich repeat proteoglycan family (SLRPs) which also includes decorin, fibromodulin (Hedlund et al. 1994 - binding to collagen II), lumican and asporin (Hedbom & Heinegard 1993, Ezura et al. 2000). All appear to be involved in collagen fibril formation and matrix assembly (Ameye & Young 2002).

Biglycan binds collagen types I (Schönherr et al. 1995), II (Bovine, using pig byglycan - Vynios et al. 2001, Bovine, using bovine biglycan - Douglas et al. 2008), III (Bovine, using bovine biglycan - Douglas et al. 2008), VI (Wiberg et al. 2001, 2002, human) and IX (Chen et al. 2006 - species source of collagen/biglycan unknown).

Literature References

PubMed ID	Title	Journal	Year
16293224	Interactions between collagen IX and biglycan measured by atomic force microscopy Chen, CH, Yeh, ML, Geyer, M, Wang, GJ, Huang, MH, Heggeness, MH, Höök, M, Luo, ZP	Biochem. Biophys. Res. Commun.	2006
7852349	Interaction of biglycan with type I collagen Schönherr, E, Witsch-Prehm, P, Harrach, B, Robenek, H, Rauterberg, J, Kresse, H	J. Biol. Chem.	1995
11259413	Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix Wiberg, C, Hedbom, E, Khairullina, A, Lamandé, SR, Oldberg, A, Timpl, R, Mörgelin, M, Heinegård, D	J. Biol. Chem.	2001