BGN binds Collagen types I, VI, (IX)

Stable Identifier
R-HSA-2466106
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Biglycan binds Collagen types I, VI, (IX)
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Biglycan is a member of the small leucine-rich repeat proteoglycan family (SLRPs) which also includes decorin, fibromodulin (Hedlund et al. 1994 - binding to collagen II), lumican and asporin (Hedbom & Heinegard 1993, Ezura et al. 2000). All appear to be involved in collagen fibril formation and matrix assembly (Ameye & Young 2002).

Biglycan binds collagen types I (Schönherr et al. 1995), II (Bovine, using pig byglycan - Vynios et al. 2001, Bovine, using bovine biglycan - Douglas et al. 2008), III (Bovine, using bovine biglycan - Douglas et al. 2008), VI (Wiberg et al. 2001, 2002, human) and IX (Chen et al. 2006 - species source of collagen/biglycan unknown).

Literature References
PubMed ID Title Journal Year
7852349 Interaction of biglycan with type I collagen

Schönherr, E, Witsch-Prehm, P, Harrach, B, Robenek, H, Rauterberg, J, Kresse, H

J. Biol. Chem. 1995
16293224 Interactions between collagen IX and biglycan measured by atomic force microscopy

Chen, CH, Yeh, ML, Geyer, M, Wang, GJ, Huang, MH, Heggeness, MH, Höök, M, Luo, ZP

Biochem. Biophys. Res. Commun. 2006
11259413 Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix

Wiberg, C, Hedbom, E, Khairullina, A, Lamandé, SR, Oldberg, A, Timpl, R, Mörgelin, M, Heinegård, D

J. Biol. Chem. 2001
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