RLBP1 binds atROL to form RLBP1:atROL

Stable Identifier
R-HSA-2465971
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Retinaldehyde-binding protein 1 (RLBP1, also called cellular retinaldehyde-binding protein, CRALBP) (Crabb et al. 1998) binds 11cROL (He et al. 2009) and is thought to enhance the activity of isomerase II and ARAT in experiments performed in cone-rich eyes from chickens (Mata et al. 2002, Mata et al. 2005).

Literature References
PubMed ID Title Journal Year
12367507 Isomerization and oxidation of vitamin a in cone-dominant retinas: a novel pathway for visual-pigment regeneration in daylight.

Mata, NL, Radu, RA, Clemmons, RC, Travis, GH

Neuron 2002
16128572 Chicken retinas contain a retinoid isomerase activity that catalyzes the direct conversion of all-trans-retinol to 11-cis-retinol

Mata, NL, Ruiz, A, Radu, RA, Bui, TV, Travis, GH

Biochemistry 2005
9541407 Structural and functional characterization of recombinant human cellular retinaldehyde-binding protein

Crabb, JW, Carlson, A, Chen, Y, Goldflam, S, Intres, R, West, KA, Hulmes, JD, Kapron, JT, Luck, LA, Horwitz, J, Bok, D

Protein Sci. 1998
19846785 Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W

He, X, Lobsiger, J, Stocker, A

Proc. Natl. Acad. Sci. U.S.A. 2009
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