OPN1SW, OPN1MW, OPN1LW bind 11cRAL

Stable Identifier
R-HSA-2465924
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
11cRAL binds cone opsins
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Human apo opsin proteins covalently bind the chromophore 11-cis-retinal (11cRAL) via a Schiff base linkage to a lysine residue in the seventh transmembrane alpha helix that is conserved in all known opsins (see review Shichida & Matsuyama 2009). The Schiff base linkage effectively results in an 11-cis-retinyl (11c-retinyl) group covalently linking to a lysine residue of opsins with subsequent loss of water. The three human cone opsins are Long Wavelength Sensitive Opsin (OPN1LW), Short Wavelength Sensitive Opsin (OPN1SW) and Middle Wavelength Sensitive Opsin (OPN1MW), sensing red, blue and green regions of the light spectrum, respectively (Nathans et al. 1986, Nathans et al. 1986b, Oprian et al. 1991).

Literature References
PubMed ID Title Journal Year
2937147 Molecular genetics of human color vision: the genes encoding blue, green, and red pigments

Nathans, J, Thomas, D, Hogness, DS

Science 1986
1742276 Design, chemical synthesis, and expression of genes for the three human color vision pigments

Oprian, DD, Asenjo, AB, Lee, N, Pelletier, SL

Biochemistry 1991
3485310 Molecular genetics of inherited variation in human color vision

Nathans, J, Piantanida, TP, Eddy, RL, Shows, TB, Hogness, DS

Science 1986
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