Reactome | DDR2 binds collagen type I, II, III, V, X fibrils

DDR2 binds collagen type I, II, III, V, X fibrils

Stable Identifier

R-HSA-2465890

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

Synonyms

Discoidin domain receptor 2 binds collagens

ReviewStatus

5/5

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DDR2 binds collagen type I, II, III, V, X fibrils

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Discoidin domain receptors (DDRs) are a subfamily of receptor tyrosine kinases, the only members known to respond to an ECM component. DDR2 binds the major fibrillar collagens types I, II, III, and V) and the non-fibrillar collagen X (Shrivastava et al. 1997, Vogel et al. 1997, Leitinger & Kwan 2006). DDR proteins bind collagen as dimers (Leitinger 2003, 2011). DDR2 is confined to mesenchymal cells where it controls developmental processes and regulates cell adhesion, migration, proliferation, and remodelling of the extracellular matrix by controlling the expression and activity of matrix metalloproteinases (Leitinger & Hohenester 2007).

Literature References

PubMed ID	Title	Journal	Year
9659900	An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors Campbell, E, Kovac, L, Glass, DJ, Lemke, G, Goldfarb, MP, Radziejewski, C, Yancopoulos, GD, Davis, S, Shrivastava, A, McGlynn, M, Ryan, TE	Mol. Cell	1997
16806867	The discoidin domain receptor DDR2 is a receptor for type X collagen Kwan, AP, Leitinger, B	Matrix Biol.	2006