DDR2 binds collagen type I, II, III, V, X fibrils

Stable Identifier
R-HSA-2465890
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Discoidin domain receptor 2 binds collagens
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Discoidin domain receptors (DDRs) are a subfamily of receptor tyrosine kinases, the only members known to respond to an ECM component. DDR2 binds the major fibrillar collagens types I, II, III, and V) and the non-fibrillar collagen X (Shrivastava et al. 1997, Vogel et al. 1997, Leitinger & Kwan 2006). DDR proteins bind collagen as dimers (Leitinger 2003, 2011). DDR2 is confined to mesenchymal cells where it controls developmental processes and regulates cell adhesion, migration, proliferation, and remodelling of the extracellular matrix by controlling the expression and activity of matrix metalloproteinases (Leitinger & Hohenester 2007).

Literature References
PubMed ID Title Journal Year
16806867 The discoidin domain receptor DDR2 is a receptor for type X collagen

Leitinger, B, Kwan, AP

Matrix Biol. 2006
9659900 An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors

Shrivastava, A, Radziejewski, C, Campbell, E, Kovac, L, McGlynn, M, Ryan, TE, Davis, S, Goldfarb, MP, Glass, DJ, Lemke, G, Yancopoulos, GD

Mol. Cell 1997
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