DDR2 binds collagen type I, II, III, V, X fibrils

Stable Identifier
Reaction [binding]
Homo sapiens
Discoidin domain receptor 2 binds collagens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Discoidin domain receptors (DDRs) are a subfamily of receptor tyrosine kinases, the only members known to respond to an ECM component. DDR2 binds the major fibrillar collagens types I, II, III, and V) and the non-fibrillar collagen X (Shrivastava et al. 1997, Vogel et al. 1997, Leitinger & Kwan 2006). DDR proteins bind collagen as dimers (Leitinger 2003, 2011). DDR2 is confined to mesenchymal cells where it controls developmental processes and regulates cell adhesion, migration, proliferation, and remodelling of the extracellular matrix by controlling the expression and activity of matrix metalloproteinases (Leitinger & Hohenester 2007).

Literature References
PubMed ID Title Journal Year
9659900 An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors

Campbell, E, Kovac, L, Glass, DJ, Lemke, G, Goldfarb, MP, Radziejewski, C, Yancopoulos, GD, Davis, S, Shrivastava, A, McGlynn, M, Ryan, TE

Mol. Cell 1997
16806867 The discoidin domain receptor DDR2 is a receptor for type X collagen

Kwan, AP, Leitinger, B

Matrix Biol. 2006
Orthologous Events
Cite Us!