RDH12 reduces atRAL to atROL

Stable Identifier
R-HSA-2464822
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, photoreceptor inner segment membrane
ReviewStatus
5/5
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RDH12 reduces atRAL to atROL
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The reversible, NADP(H)-dependent reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL) occurs in both rod and cone photoreceptor cells where multiple retinol dehydrogenases (RHDs) are located. RHDs belong to the short-chain dehydrogenase/reductase (SDR) superfamily. RDH12 (located in photoreceptor inner segments) is partially responsible, together with other RDHs, for mediating this reaction (Belyaeva et al. 2005).
Literature References
Participants
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Output
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as an event of
Catalyst Activity

all-trans-retinol dehydrogenase (NADP+) activity of RDH12 [photoreceptor inner segment membrane]

Physical Entity
RDH12 [photoreceptor inner segment membrane] (Homo sapiens)
Activity
all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)
Orthologous Events
RDH12 reduces atRAL to atROL (Bos taurus)
RDH12 reduces atRAL to atROL (Canis familiaris)
RDH12 reduces atRAL to atROL (Danio rerio)
RDH12 reduces atRAL to atROL (Drosophila melanogaster)
RDH12 reduces atRAL to atROL (Gallus gallus)
RDH12 reduces atRAL to atROL (Mus musculus)
RDH12 reduces atRAL to atROL (Rattus norvegicus)
RDH12 reduces atRAL to atROL (Sus scrofa)
Cross References
Rhea
Authored
Jassal, B  (2012-09-03)
Reviewed
Blaner, WS  (2013-01-31)
Created
Jassal, B  (2012-09-03)
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