RDH12 reduces atRAL to atROL

Stable Identifier
R-HSA-2464822
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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The reversible, NADP(H)-dependent reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL) occurs in both rod and cone photoreceptor cells where multiple retinol dehydrogenases (RHDs) are located. RHDs belong to the short-chain dehydrogenase/reductase (SDR) superfamily. RDH12 (located in photoreceptor inner segments) is partially responsible, together with other RDHs, for mediating this reaction (Belyaeva et al. 2005).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NADP-retinol dehydrogenase activity of RDH12 [photoreceptor inner segment membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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