Reactome | RBP3 transports 11cRAL to rod photoreceptor outer segment

RBP3 transports 11cRAL to rod photoreceptor outer segment

Stable Identifier

R-HSA-2454113

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region

ReviewStatus

5/5

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RBP3 transports 11cRAL to rod photoreceptor outer segment

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Interphotoreceptor retinoid-binding protein (RBP3) is the major soluble protein in the interphotoreceptor matrix (IPM) (Liou et al. 1989, Fong & Bridges 1988). It is thought to shuttle 11-cis-retinal (11cRAL) between retinal pigment epithelium (RPE) and photoreceptor outer segments during the visual cycle but the mechanism is poorly understood (Gonzalez-Fernandez & Ghosh 2008).

Literature References

PubMed ID	Title	Journal	Year
3170584	Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA Bridges, CD, Fong, SL	J. Biol. Chem.	1988
2542268	Human interstitial retinoid-binding protein. Gene structure and primary structure Geng, L, Zhu, C, Liou, GI, Ma, DP, Baehr, W, Yang, YW	J. Biol. Chem.	1989