Reactome | TTR:RBP:atROL binds to STRA6 receptor

TTR:RBP:atROL binds to STRA6 receptor

Stable Identifier

R-HSA-2453876

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

All-trans-retinol (atROL) circulates in the bloodstream in complex with transthyretin (TTR) and retinol- binding protein 4 (RBP4). The receptor Stimulated by retinoic acid gene 6 protein homologue (STRA6) acts as a high-affinity cell-surface receptor for the complex (Berry et al. 2012), removing atROL and transporting it into tissues expressing STRA6, including the eyes (Kawaguchi et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
22665496	Cross Talk between Signaling and Vitamin A Transport by the Retinol-Binding Protein Receptor STRA6 Noy, N, Berry, DC, O'Byrne, SM, Blaner, WS, Vreeland, AC	Mol. Cell. Biol.	2012
17255476	A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A Yu, J, Whitelegge, J, Honda, J, Sun, H, Bok, D, Ping, P, Hu, J, Wiita, P, Kawaguchi, R	Science	2007