TTR:RBP:atROL binds to STRA6 receptor

Stable Identifier
R-HSA-2453876
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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All-trans-retinol (atROL) circulates in the bloodstream in complex with transthyretin (TTR) and retinol- binding protein 4 (RBP4). The receptor Stimulated by retinoic acid gene 6 protein homologue (STRA6) acts as a high-affinity cell-surface receptor for the complex (Berry et al. 2012), removing atROL and transporting it into tissues expressing STRA6, including the eyes (Kawaguchi et al. 2007).

Literature References
PubMed ID Title Journal Year
17255476 A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A

Kawaguchi, R, Yu, J, Honda, J, Hu, J, Whitelegge, J, Ping, P, Wiita, P, Bok, D, Sun, H

Science 2007
22665496 Cross Talk between Signaling and Vitamin A Transport by the Retinol-Binding Protein Receptor STRA6

Berry, DC, O'Byrne, SM, Vreeland, AC, Blaner, WS, Noy, N

Mol. Cell. Biol. 2012
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