STRA6 transports atROL from extracellular region to cytosol

Stable Identifier
R-HSA-2453863
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
Synonyms
All-trans-retinol is taken up by cells expressing STRA6 receptor
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Stimulated by retinoic acid gene 6 protein homologue (STRA6) acts as a high-affinity cell-surface receptor for the TTR:RBP4:atROL complex (Berry et al. 2012). Once bound, STRA6 removes atROL and transports it into cells expressing STRA6 receptors, including eye (Kawaguchi et al. 2007). Defects in STRA6 cause microphthalmia syndromic type 9 (MCOPS9, Matthew-Wood syndrome or Spear syndrome; MIM:601186) (Chassaing et al. 2009). The uptake of atROL is driven by the conversion of atROL to retinyl ester (RE) by LRAT (Kawaguchi et al. 2011).

Literature References
PubMed ID Title Journal Year
17255476 A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A

Kawaguchi, R, Yu, J, Honda, J, Hu, J, Whitelegge, J, Ping, P, Wiita, P, Bok, D, Sun, H

Science 2007
22665496 Cross Talk between Signaling and Vitamin A Transport by the Retinol-Binding Protein Receptor STRA6

Berry, DC, O'Byrne, SM, Vreeland, AC, Blaner, WS, Noy, N

Mol. Cell. Biol. 2012
21774515 Receptor-mediated cellular uptake mechanism that couples to intracellular storage

Kawaguchi, R, Yu, J, Ter-Stepanian, M, Zhong, M, Cheng, G, Yuan, Q, Jin, M, Travis, GH, Ong, D, Sun, H

ACS Chem. Biol. 2011
19309693 Phenotypic spectrum of STRA6 mutations: from Matthew-Wood syndrome to non-lethal anophthalmia

Chassaing, N, Golzio, C, Odent, S, Lequeux, L, Vigouroux, A, Martinovic-Bouriel, J, Tiziano, FD, Masini, L, Piro, F, Maragliano, G, Delezoide, AL, AttiƩ-Bitach, T, Manouvrier-Hanu, S, Etchevers, HC, Calvas, P

Hum. Mutat. 2009
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