p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D

Stable Identifier
R-HSA-2430552
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D
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ARPP19 and ENSA, activated by MASTL (GWL) mediated phosphorylation, bind and inhibit PP2A complexed with the regulatory subunit PPP2R2D (B55-delta). Inhibition of PP2A-PPP2R2D phosphatase activity allows mitotis entry and mainetance by preventing dephosphorylation of CDK1 mitotic targets (Mochida et al. 2010, Gharbi-Ayachi et al. 2010).

Literature References
PubMed ID Title Journal Year
21164013 Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis

Skehel, M, Mochida, S, Hunt, T, Maslen, SL

Science 2010
21164014 The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

Lorca, T, Burgess, A, Van-Dorsselaer, A, Vigneron, S, Strub, JM, Gharbi-Ayachi, A, Castro, A, Brioudes, E, Labbe, JC

Science 2010
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Inferred From
p-S67-Ensa/p-S67-Arpp19 binds PP2A-Ppp2r2d (Xenopus laevis)
Authored
Orlic-Milacic, M  (2012-09-04)
Reviewed
Mochida, S  (2012-09-26)
Burgess, A  (2012-09-28)
Created
Orlic-Milacic, M  (2012-08-10)
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