ARPP19 and ENSA, activated by MASTL (GWL) mediated phosphorylation, bind and inhibit PP2A complexed with the regulatory subunit PPP2R2D (B55-delta). Inhibition of PP2A-PPP2R2D phosphatase activity allows mitotis entry and mainetance by preventing dephosphorylation of CDK1 mitotic targets (Mochida et al. 2010, Gharbi-Ayachi et al. 2010).
Skehel, M, Mochida, S, Hunt, T, Maslen, SL
Lorca, T, Burgess, A, Van-Dorsselaer, A, Vigneron, S, Strub, JM, Gharbi-Ayachi, A, Castro, A, Brioudes, E, Labbe, JC
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