p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D

Stable Identifier
R-HSA-2430552
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D
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ARPP19 and ENSA, activated by MASTL (GWL) mediated phosphorylation, bind and inhibit PP2A complexed with the regulatory subunit PPP2R2D (B55-delta). Inhibition of PP2A-PPP2R2D phosphatase activity allows mitotis entry and mainetance by preventing dephosphorylation of CDK1 mitotic targets (Mochida et al. 2010, Gharbi-Ayachi et al. 2010).

Literature References
PubMed ID Title Journal Year
21164014 The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

Gharbi-Ayachi, A, Labbe, JC, Burgess, A, Vigneron, S, Strub, JM, Brioudes, E, Van-Dorsselaer, A, Castro, A, Lorca, T

Science 2010
21164013 Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis

Mochida, S, Maslen, SL, Skehel, M, Hunt, T

Science 2010
Participants
Input
Output
Participant Of
hasEvent
Inferred From
p-S67-Ensa/p-S67-Arpp19 binds PP2A-Ppp2r2d (Xenopus laevis)
Cross References
Target Pathogen
Authored
Orlic-Milacic, M  (2012-09-04)
Reviewed
Mochida, S  (2012-09-26)
Burgess, A  (2012-09-28)
Created
Orlic-Milacic, M  (2012-08-10)
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