ARPP19 and ENSA, activated by MASTL (GWL) mediated phosphorylation, bind and inhibit PP2A complexed with the regulatory subunit PPP2R2D (B55-delta). Inhibition of PP2A-PPP2R2D phosphatase activity allows mitotis entry and mainetance by preventing dephosphorylation of CDK1 mitotic targets (Mochida et al. 2010, Gharbi-Ayachi et al. 2010).
Gharbi-Ayachi, A, Labbe, JC, Burgess, A, Vigneron, S, Strub, JM, Brioudes, E, Van-Dorsselaer, A, Castro, A, Lorca, T
Mochida, S, Maslen, SL, Skehel, M, Hunt, T
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